{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:22:49Z","timestamp":1792606969546,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The current research explored the possible protective effect of <jats:italic>chenopodium quinoa<\/jats:italic> extract against CCl<jats:sub>4<\/jats:sub> acute liver toxicity in Sprague Dawley rats. Thirty rats were divided into five groups with six rats in each group. CCl<jats:sub>4<\/jats:sub> (Carbon tetrachloride) was administered at a dose rate of 2\u2009mL\/kg b.w. intra\u2010peritoneally once a week for 3\u2009weeks. The plant extract was given through oral gavage for a period of 21\u2009days. Group I served as a normal group which was given with basal diet. Group II was referred to as a positive control group and received CCl<jats:sub>4<\/jats:sub> 2\u2009mL\/kg body weight (i.p.). Group III was the standard treatment group and received 2\u2009mL\/kg CCl<jats:sub>4<\/jats:sub> (i.p.) and 16\u2009mg\/kg body weight (p.o.) silymarin. Group IV was the plant treatment group, which received 2\u2009mL\/kg CCl<jats:sub>4<\/jats:sub> (i.p.) and 600\u2009mg\/kg body weight of quinoa seed extract (p.o.). Group V was the combined treatment group, which received 2\u2009mL\/kg CCl<jats:sub>4<\/jats:sub> (i.p.) accompanied with a combination of silymarin (p.o.) 16\u2009mg\/kg body weight and quinoa seed extract (p.o.) 600\u2009mg\/kg body weight. The liver biomarkers were assessed along with histopathological analysis to observe the changes in the liver. The outcome suggested that the treatment, which was given with the combination of silymarin and quinoa seed extract, significantly enhanced the antioxidant levels, reduced the oxidative stress, and restored the liver function as evidenced by biochemical parameters histopathological studies. The hepatoprotective potential may be due to the antioxidant and anti\u2010inflammatory properties of quinoa seed extract.<\/jats:p>","DOI":"10.1002\/fsn3.4149","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T09:49:46Z","timestamp":1712224186000},"page":"5007-5018","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hepatoprotective efficacy of quinoa seed extract against <scp>CCl<sub>4<\/sub><\/scp>\u2010 induced acute liver toxicity in rat model"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1403-0590","authenticated-orcid":false,"given":"Maria","family":"Arshad","sequence":"first","affiliation":[{"name":"National Institute of Food Science and Technology (NIFSAT), University of Agriculture  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabana","family":"Kousar","sequence":"additional","affiliation":[{"name":"National Institute of Food Science and Technology (NIFSAT), University of Agriculture  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Din","sequence":"additional","affiliation":[{"name":"National Institute of Food Science and Technology (NIFSAT), University of Agriculture  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9047-9075","authenticated-orcid":false,"given":"Muhammad","family":"Afzaal","sequence":"additional","affiliation":[{"name":"Department of Food Science Government College University Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6448-9325","authenticated-orcid":false,"given":"Muhammad Naeem","family":"Faisal","sequence":"additional","affiliation":[{"name":"National Institute of Food Science and Technology (NIFSAT), University of Agriculture  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian Kamran","family":"Sharif","sequence":"additional","affiliation":[{"name":"National Institute of Food Science and Technology (NIFSAT), University of Agriculture  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Rasheed","sequence":"additional","affiliation":[{"name":"National Institute of Food Science and Technology (NIFSAT), University of Agriculture  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5340-4015","authenticated-orcid":false,"given":"Farhan","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Food Science Government College University Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2100-6212","authenticated-orcid":false,"given":"Noor","family":"Akram","sequence":"additional","affiliation":[{"name":"Food Safety &amp; 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