{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T18:17:34Z","timestamp":1773944254603,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008783","name":"National Research Council of Science and Technology","doi-asserted-by":"publisher","award":["CAP21023\u2010000"],"award-info":[{"award-number":["CAP21023\u2010000"]}],"id":[{"id":"10.13039\/501100008783","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","award":["KSN1823320"],"award-info":[{"award-number":["KSN1823320"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cachexia is associated with various diseases, such as heart disease, infectious disease, and cancer. In particular, cancer\u2010associated cachexia (CAC) accounts for more than 20% of mortality in cancer patients worldwide. Adipose tissue in CAC is characterized by adipocyte atrophy, mainly due to excessively increased lipolysis and impairment of adipogenesis. CAC is well known for the loss of skeletal muscle mass and\/or fat mass. CAC induces severe metabolic alterations, including protein, lipid, and carbohydrate metabolism. The objectives of this study were to evaluate the effects of bee wax (<jats:italic>Apis mellifera<\/jats:italic> L. 1758) (BW) extract on adipogenesis, lipolysis, and mitochondrial oxygen consumption through white adipocytes, 3T3\u2010L1. To achieve this study, cancer\u2010associated cachexia condition was established by incubation of 3T3\u2010L1 with colon cancer cell line CT26 cultured media. BW extract recovered the reduced adipogenesis under cachectic conditions in CT26 media. Treatment of BW showed increasing lipid accumulation as well as adipogenic gene expression and its target gene during adipogenesis. The administration of BW to adipocytes could decrease lipolysis. Also, BW could significantly downregulated the mitochondrial fatty acid oxidation\u2010related genes, oxygen consumption rate, and extracellular acidification rate. Our results suggest that BW could improve metabolic disorders such as CAC through the activation of adipogenesis and inhibition of lipolysis in adipocytes, although we need further validation in\u00a0vivo CAC model to check the effects of BW extract. Therefore, BW extract supplements could be useful as an alternative medicine to reverse energy imbalances.<\/jats:p>","DOI":"10.1002\/fsn3.4153","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T06:14:20Z","timestamp":1713420860000},"page":"5027-5035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bee (<i>Apis mellifera<\/i> L. 1758) wax restores adipogenesis and lipid accumulation of <scp>3T3\u2010L1<\/scp> cells in cancer\u2010associated cachexia condition"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2261-0067","authenticated-orcid":false,"given":"Hyun\u2010Jun","family":"Jang","sequence":"first","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Korea"},{"name":"Research Group of Personalized Diet Korea Food Research Institute  Wanju\u2010gun Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Yong","family":"Kim","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hyo","family":"Lyu","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subramanian","family":"Muthamil","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ung Cheol","family":"Shin","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Seon","family":"Kim","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieun","family":"Jeong","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Oncolomics, Department of Biomedical Science, College of Medicine University of Ulsan  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suwhan","family":"Chang","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Oncolomics, Department of Biomedical Science, College of Medicine University of Ulsan  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Oncolomics, Department of Biomedical Science, College of Medicine University of Ulsan  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Hong","family":"Park","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Korea"},{"name":"Korean Convergence Medicine Major University of Science &amp; 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