{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:01:20Z","timestamp":1792508480191,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Gracilaria chorda<\/jats:italic> (GC) is a red algal species that is primarily consumed in Asia. Here, we investigated the effect of GC on obesity\u2010related skeletal muscle wasting. Furthermore, elucidating its impact on the activation of sirtuin 1 (SIRT1)\/peroxisome proliferator\u2010activated receptor gamma coactivator 1\u03b1 (PGC1\u03b1) constituted a critical aspect in understanding the underlying mechanism of action. In this study, 6\u2010week\u2010old male C57BL\/6 mice were fed a high\u2010fat diet (HFD) for 8\u2009weeks to induce obesity, then continued on the HFD for another 8 weeks while orally administered GC. GC decreased ectopic fat accumulation in skeletal muscle and increased muscle weight, size, and function in obese mice. Furthermore, GC reduced skeletal muscle atrophy and increased hypertrophy in mice. We hypothesized that the activation of SIRT1\/PGC1\u03b1 by GC regulates skeletal muscle atrophy and hypertrophy. We observed that GC increased the expression of SIRT1 and PGC1\u03b1 in skeletal muscle of mice and in C2C12 cells, which increased mitochondrial function and biogenesis. In addition, when C2C12 cells were treated with the SIRT1\u2010specific inhibitor EX\u2010527, no changes were observed in the protein levels of SIRT1 and PGC1\u03b1 in the GC\u2010treated C2C12 cells. Therefore, GC attenuated obesity\u2010related muscle wasting by improving mitochondrial function and biogenesis through the activation of SIRT1\/PGC1\u03b1 in the skeletal muscle of mice.<\/jats:p>","DOI":"10.1002\/fsn3.4157","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T04:38:59Z","timestamp":1712291939000},"page":"5077-5086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>Gracilaria chorda<\/i> attenuates obesity\u2010related muscle wasting through activation of <scp>SIRT1<\/scp>\/<scp>PGC1\u03b1<\/scp> in skeletal muscle of mice"],"prefix":"10.1002","volume":"12","author":[{"given":"Ahyoung","family":"Yoo","sequence":"first","affiliation":[{"name":"Division of Food Functionality Research Korea Food Research Institute  Wanju\u2010gun 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