{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:42:21Z","timestamp":1786977741804,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011696","name":"Shahed University","doi-asserted-by":"publisher","award":["22780"],"award-info":[{"award-number":["22780"]}],"id":[{"id":"10.13039\/501100011696","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Globally, iron deficiency reigns as the most prevalent nutritional disorder, with anemia disproportionately impacting women of childbearing age. Despite the effectiveness of existing treatments, like iron supplements, their side effects remain a concern. This study explores the potential of grape syrup (GS), a functional iron\u2010rich food, to modulate markers of iron\u2010deficient anemia in women. A randomized, double\u2010blind study explored the impact of GS on iron deficiency anemia markers in 130 women. Participants were allocated to intervention or placebo groups. For 4\u2009weeks, the intervention group received a daily 50\u2009mg ferrous sulfate tablet alongside 10\u2009cc of GS thrice daily. The placebo group received a 50\u2009mg ferrous sulfate tablet with a 10\u2009cc placebo syrup thrice daily. Before and after the intervention, key markers like red blood cell count (RBC), mean corpuscular volume (MCV), hemoglobin (Hb), hematocrit (Hct), ferritin, total iron binding capacity (TIBC), and serum iron were assessed. Notably, both Hb and Hct levels were significantly higher in the GS group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). Additionally, RBC and MCV values showed significant improvement compared to the placebo group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). However, no significant difference was observed for other iron deficiency markers like serum iron, ferritin, and TIBC (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u2009.05). This study's findings suggest that combining grape syrup with iron tablets might offer potential advantages over iron tablets alone in managing iron deficiency anemia.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.4185","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T06:03:52Z","timestamp":1714975432000},"page":"5473-5479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating the effect of grape syrup on iron deficiency anemia in women: A randomized clinical trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8598-3692","authenticated-orcid":false,"given":"Rasul","family":"Pourhakim","sequence":"first","affiliation":[{"name":"Department of Traditional Medicine, School of Persian Medicine Shahed University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0573-7143","authenticated-orcid":false,"given":"Fatemeh","family":"Emadi","sequence":"additional","affiliation":[{"name":"Department of Traditional Medicine, School of Persian Medicine Shahed University  Tehran Iran"},{"name":"Traditional Medicine Clinical Trial Research Center Shahed University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Razavi\u00a0Dizaji","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Urmia University of Medical Sciences  Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryush","family":"Talei","sequence":"additional","affiliation":[{"name":"Medicinal Plants Research Center Shahed University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed Saeed","family":"Esmaeili\u00a0Saber","sequence":"additional","affiliation":[{"name":"Department of Traditional Medicine, School of Persian Medicine Shahed University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Iranzadasl","sequence":"additional","affiliation":[{"name":"Department of Traditional Medicine, School of Persian Medicine Shahed University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.24925\/turjaf.v9i6.1106\u20101113.4302"},{"key":"e_1_2_11_3_1","first-page":"465","article-title":"Absorption of iron from grape\u2010molasses and ferrous sulfate: A comparative study in normal subjects and subjects with iron deficiency anemia","volume":"39","author":"Aslan Y.","year":"1997","journal-title":"The Turkish Journal of Pediatrics"},{"key":"e_1_2_11_4_1","unstructured":"Avicenna. (2005).Al\u2010Qanun fi al\u2010Tibb (The Canon of Medicine). Beirut: D\u0101r Ihy\u0101' al\u2010Tur\u0101th al\u2010Arab\u012b. [In Arabic]."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2022.2108255"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/microbiolres12020033"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2015.1.8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13004"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.97204"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.47552\/ijam.v11i1.1334"},{"key":"e_1_2_11_11_1","first-page":"35","article-title":"Effect of different clarifying agents on the physico\u2010chemical and microbial properties of grape juice concentrate","volume":"5","author":"Hatamikia M.","year":"2013","journal-title":"Journal of Innovation in Food Science and Technology"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.12991\/mpj.2018.39"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010020\u201007607\u20109"},{"key":"e_1_2_11_14_1","unstructured":"INSO. (2012).Grape syrup concentrate\u2014Specification and test methods. Standard no. 14725. First edition."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfpe.12406"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.31127\/tuje.623785"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678\u20104324\u20102021200027"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010020\u201001564\u2010y"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.29252\/fsct.16.97.101"},{"key":"e_1_2_11_20_1","first-page":"336","article-title":"Reliability, validity and factor structure of the persian translation of general health questionnire (ghq\u201028) in hospitals of kerman university of medical sciences","volume":"3","author":"Nazifi M.","year":"2014","journal-title":"Journal of Fasa University of Medical Sciences"},{"key":"e_1_2_11_21_1","first-page":"104","article-title":"Anaemia: A disease or symptom","volume":"78","author":"Newhall D.","year":"2020","journal-title":"The Netherlands Journal of Medicine"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/2156587214542006"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2019000034"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgfs.2022.100628"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1150"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.6846"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3107"},{"key":"e_1_2_11_28_1","first-page":"4908","article-title":"Grape shinny for prevention and nutritional support of micronutrient deficiency in mothers and children","volume":"7","author":"Rasulov S.","year":"2020","journal-title":"European Journal of Molecular & Clinical Medicine"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1586"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/aca.aca_209_20"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2891"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfpe.13547"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117383"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.11.139"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2373"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.4185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.4185","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.4185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:13:46Z","timestamp":1779117226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.4185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,6]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/fsn3.4185"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.4185","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,6]]},"assertion":[{"value":"2023-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}