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In response, the search for new anticancer compounds from plants has intensified, given their historical success in yielding effective treatments. This review focuses on \u03b1\u2010solanine, a glycoalkaloid primarily derived from potato tubers and nightshade family plants, recognized for its diverse biological activities, including anti\u2010allergic, antipyretic, anti\u2010inflammatory, anti\u2010diabetic, and antibiotic properties. Recently, \u03b1\u2010solanine has gained attention as a potential anticancer agent. Utilizing resources like PubMed\/MedLine, ScienceDirect, Web of Science, Scopus, the American Chemical Society, Google Scholar, Springer Link, Wiley, and various commercial websites, this review consolidates two decades of research on \u03b1\u2010solanine's anticancer effects and mechanisms against nine different cancers, highlighting its role in modulating various signaling pathways. It also discusses \u03b1\u2010solanine's potential as a lead compound in cancer therapy. The abundant availability of potato peel, often discarded as waste or sold cheaply, is suggested as a sustainable source for large\u2010scale \u03b1\u2010solanine extraction. The study concludes that \u03b1\u2010solanine holds promise as a standalone or adjunctive cancer treatment. 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