{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:54:44Z","timestamp":1792076084574,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aims to elucidate the detailed metabolic implications of varying monacolin K levels and sterilization methods on\n                    <jats:italic>Monascus<\/jats:italic>\n                    \u2010fermented rice products (MFRPs), acclaimed for their health benefits and monacolin K content. Advanced metabolite profiling of various MFRP variants was conducted using ultrahigh\u2010performance liquid chromatography coupled with tandem time\u2010of\u2010flight mass spectrometry (UHPLC\u2010Q\u2010TOF MS). Statistical analysis encompassed\n                    <jats:italic>t<\/jats:italic>\n                    \u2010tests, ANOVA, and multivariate techniques including PCA, PLS\u2010DA, and OPLS\u2010DA. Notable variations in metabolites were observed across MFRPs with differing monacolin K levels, particularly in variants such as MR1\u2010S, MR1.5\u2010S, MR2\u2010S, and MR3\u2010S. Among the 524 identified metabolites, significant shifts were noted in organic acids, derivatives, lipids, nucleosides, and organic oxygen compounds. The study also uncovered distinct metabolic changes resulting from different sterilization methods and the use of highland barley as a fermentation substitute for rice. Pathway analysis shed light on affected metabolic pathways, including those involved in longevity regulation, cGMP\u2010PKG signaling, and the biosynthesis of unsaturated fatty acids. The research provides critical insights into the complex metabolic networks of MFRPs, underscoring the impact of fermentation substrates and conditions on monacolin K levels and their health implications. This study not only guides the nutritional optimization of MFRPs but also emphasizes the strategic importance of substrate choice and sterilization techniques in enhancing the nutritional and medicinal value of these functional foods.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.4222","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T01:39:34Z","timestamp":1715650774000},"page":"5587-5604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Metabolomic insights into\n                    <scp>\n                      <i>Monascus<\/i>\n                    <\/scp>\n                    \u2010fermented rice products: Implications for monacolin K content and nutritional optimization"],"prefix":"10.1002","volume":"12","author":[{"given":"Yongxia","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pharmacognostics Zunyi Medical University  Zunyi China"},{"name":"Guizhou Yuanxi Biological R &amp; D Co., Ltd.  Guiyang China"},{"name":"Tibet Yuewang Medicine Diagnosis Ecological Tibetan Medicine Technology Co., Ltd.  Lasha China"},{"name":"School of Life Sciences Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pharmacognostics Zunyi Medical University  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacognostics Zunyi Medical University  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pharmacognostics Zunyi Medical University  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacognostics Zunyi Medical University  Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Bai","sequence":"additional","affiliation":[{"name":"Guizhou Yuanxi Biological R &amp; D Co., Ltd.  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Tibet Yuewang Medicine Diagnosis Ecological Tibetan Medicine Technology Co., Ltd.  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