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Although antimicrobial studies have been conducted with several species of the <jats:italic>Iris<\/jats:italic> genus, this study is the first in the literature to be performed with <jats:italic>Iris persica<\/jats:italic> L. subsp. <jats:italic>persica<\/jats:italic> aqueous and methanol extracts. In this study, the phenolic content of <jats:italic>I. persica<\/jats:italic> was determined by LC\u2013MS\/MS analysis, the in vitro antimicrobial activity of <jats:italic>I. persica<\/jats:italic> aqueous and methanol extracts was examined, and this study was supported by in silico analysis. Consequently, methanol and aqueous extracts were observed to have inhibitory effects against all tested microorganisms except <jats:italic>Candida krusei<\/jats:italic>. Although the MIC values of aqueous extract and methanol extract against <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Klebsiella pneumoniae<\/jats:italic> are the same (22.5 and 11.25\u2009mg\/mL, respectively), the inhibitory effect of aqueous extract is generally more potent (MIC value is 11.25\u2009mg\/mL for <jats:italic>Candida parapsilosis<\/jats:italic> and other bacterial species, and 90\u2009mg\/mL for <jats:italic>Candida albicans<\/jats:italic> and <jats:italic>Candida tropicalis<\/jats:italic>) than that of methanol extract. In silico results showed that hydroxybenzaldeyde, vanillin, resveratrol, isoquercitrin, kaempferol\u20103\u2010glucoside, fisetin, and luteolin were more prone to antifungal activity. Hence, shikimic, gallic, protocatechuic, vanillic, caffeic, <jats:italic>o<\/jats:italic>\u2010coumaric, <jats:italic>trans<\/jats:italic>\u2010ferulic, sinapic acids, and hesperidin were more prone to antibacterial activity. In vitro and in silico results show that the antibacterial activity of our extracts may be higher than the antifungal activity. This preliminary study indicates the anti\u2010infective potential of <jats:italic>I. persica<\/jats:italic> extracts and their usability in medicine and pharmacology.<\/jats:p>","DOI":"10.1002\/fsn3.4251","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T06:09:40Z","timestamp":1719295780000},"page":"6578-6594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Screening of phenolic components and antimicrobial properties of <i>Iris persica<\/i> L. subsp. <i>persica<\/i> extracts by in vitro and in silico methods"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8655-2716","authenticated-orcid":false,"given":"Tuba","family":"Unver","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Faculty of Pharmacy Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8827-8557","authenticated-orcid":false,"given":"Harun","family":"Uslu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy F\u0131rat University  Elaz\u0131\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-2447","authenticated-orcid":false,"given":"Ismet","family":"Gurhan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2345-7313","authenticated-orcid":false,"given":"Bunyamin","family":"Goktas","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy F\u0131rat University  Elaz\u0131\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"73","article-title":"Herbal drugs\u2010present status and efforts to promote and regulate cultivation","volume":"6","author":"Abhishek K.","year":"2006","journal-title":"Pharmacy Review"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.09.019"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"83","article-title":"Antioxidant and antimicrobial activities of Iris nigricans methanolic extracts containing phenolic compounds","volume":"9","author":"Al\u2010Khateeb E.","year":"2013","journal-title":"European Scientific Journal"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X1801300907"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X1701200334"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2021.112441"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161126015"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362\u2010028X.JFP\u201018\u2010014"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2014.07.022"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2011.9700471"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2478\/asn\u20102020\u20100021"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi002162d"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1078\/1438\u20104221\u201000185"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0280127"},{"key":"e_1_2_10_16_1","unstructured":"Centers for Disease Control and Prevention. 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