{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:30:15Z","timestamp":1793745015429,"version":"4.6.1"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2702901"],"award-info":[{"award-number":["2022YFC2702901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The association between serum copper and polycystic ovary syndrome (PCOS) lacks definitive conclusions, and the intricate interactions with in\u00a0vitro fertilization (IVF) cycle characteristics in infertility remain insufficiently explored. This retrospective study included 560 patients with tubal infertility (no\u2010PCOS) and 266 patients with PCOS undergoing IVF at the Affiliated Suzhou Hospital of Nanjing Medical University from January 2018 to December 2022. Patients' basic characteristics, hormonal and metabolic parameters, essential trace elements, and IVF cycle characteristics were measured and analyzed. The results revealed a significantly elevated serum copper level in the PCOS group compared to the control group [17.27 (15.54, 19.67) vs 15.4 (13.87, 17.35), \u03bcmol\/L;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001]. Spearman correlation analyses revealed a significant positive correlation between serum copper concentration and body mass index (BMI), fasting glucose (FG), triglyceride (TG), total cholesterol (TC), and low\u2010density lipoprotein (LDL) in the no\u2010PCOS group. Additionally, a notable negative correlation with high\u2010density lipoprotein (HDL) was observed (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u2212.184,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001). Within the PCOS group, serum copper concentration correlated significantly with BMI (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009.198,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.004) and TG (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009.214,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.002). The linear trend analysis indicated no significant relationship between serum copper concentration and ovarian response as well as preimplantation outcomes in both groups after adjusting for confounding factors. Our study provided evidence of elevated serum copper concentration in PCOS patients, closely associated with lipid metabolism but showing no correlation with IVF outcomes. These findings provide valuable real\u2010world data, enriching our nuanced understanding of the role of copper in female fertility.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.4258","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T01:40:33Z","timestamp":1718070033000},"page":"5979-5989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Serum copper assessment in patients with polycystic ovary syndrome and tubal infertility: A retrospective 5\u2010year study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9729-2890","authenticated-orcid":false,"given":"Yanping","family":"Liu","sequence":"first","affiliation":[{"name":"Center of Reproduction and Genetics The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University  Suzhou 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