{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:04:36Z","timestamp":1783483476293,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is crucial to explore the impact of dietary interventions on depression and develop functional antidepressant foods, due to the significant side effects and poor treatment compliance of antidepressant drugs. <jats:italic>Osmanthus fragrans<\/jats:italic> flowers are edible and medicinal materials owing to their delightful floral aroma and significant health benefits. Here, we evaluated the antidepressant effects of the ethanolic extract of <jats:italic>O. fragrans<\/jats:italic> var. <jats:italic>thunbergii<\/jats:italic> flowers (OFE) and investigated the mechanisms of action on the serotonin system and neuroinflammation, and analyzed the main chemical components of OFE. A single administration of OFE significantly reduced the immobility duration in the forced swimming and tail suspension tests in mice without affecting locomotor activity. OFE exhibited selective enhancing effects on 5\u2010HTergic function in\u00a0vivo, as demonstrated by its potentiating effects on 5\u2010hydroxytryptophan (5\u2010HTP)\u2010induced head\u2010twitch behavior and alleviation effects on reserpine\u2010induced ptosis deficits. In addition, OFE increased 5\u2010hydroxytryptamine (5\u2010HT) concentration and upregulated 5\u2010HT<jats:sub>1A<\/jats:sub> expression in reserpine\u2010treated mice, further validating its effects on 5\u2010HT transmission. Interestingly, OFE significantly alleviated microglia activation and the production of inflammatory mediators, both in reserpine\u2010treated mice in\u00a0vivo and lipopolysaccharide (LPS)\u2010stimulated BV\u20102 cells in\u00a0vitro. Additionally, 62 components in OFE were identified using ultra\u2010performance liquid chromatography quadrupole time\u2010of\u2010flight high\u2010resolution mass spectrometry, and glycoside derivatives were shown to be the major constituents of OFE. The present study showed that OFE can alleviate depressive\u2010like behaviors by modulating the serotonin system and reducing neuroinflammation. These results suggest that OFE can be valuable dietary supplements with therapeutic effects on depression.<\/jats:p>","DOI":"10.1002\/fsn3.4270","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T04:40:00Z","timestamp":1718253600000},"page":"6242-6258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The ethanolic extract of <i>Osmanthus fragrans<\/i> var. <i>thunbergii<\/i> flowers ameliorates depressive\u2010like behaviors of mice by modulating the serotonin system and suppressing neuroinflammation"],"prefix":"10.1002","volume":"12","author":[{"given":"Lu\u2010yao","family":"Luo","sequence":"first","affiliation":[{"name":"School of Pharmacy North China University of Science and Technology  Tangshan China"},{"name":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology Beijing Institute of Pharmacology and Toxicology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xue","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology Beijing Institute of Pharmacology and Toxicology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010ge","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology Beijing Institute of Pharmacology and Toxicology  Beijing China"},{"name":"Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology Beijing Institute of 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