{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:51:22Z","timestamp":1792273882262,"version":"4.4.0"},"reference-count":73,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Moringa oleifera,<\/jats:italic> a widely recognized plant more commonly known as moringa, has obtained significant research interest in recent years due to its prospective physiological advantages, including its claimed ability to counteract carcinogenesis. The moringa plant has been found to possess bioactive components that exhibit promising anticancer activities against different human cancers, such as breast cancer, prostate cancer, pancreatic cancer, etc. The cytotoxic properties of moringa seed extracts on cancerous cells have also been provided in this paper along with other notable health benefits. The extracts derived from moringa seeds inhibit cancer proliferation and promote cancer cell apoptosis through multiple signaling pathways. They also stimulated intracellular reactive oxygen species (ROS) production and subsequently induced caspase\u20103 activity. The impact of moringin and avenanthramide 2f on the stimulation of caspases 2, 4, 8, and 9 results in reduction in the proliferation of cancer cells. The results reported by research studies hold significant implications for identifying and targeting specific molecular entities that could serve as potential therapeutic targets in search of effective cancer treatments. Furthermore, the flavonoids in moringa seed can remove mitochondrial reactive oxygen species, protecting beta cells and bringing hyperglycemia under control. <jats:italic>M. oleifera<\/jats:italic> seed oil can reduce the risk of cardiovascular diseases via reduced malondialdehyde (MDA) formation and modulation of cardiac superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity. This article provides a comprehensive summary of the noteworthy discoveries derived from a rigorous investigation that explored into the impact of moringa seeds on the prevention\/reduction of various cancers and other complex diseases.<\/jats:p>","DOI":"10.1002\/fsn3.4312","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T12:03:14Z","timestamp":1720526594000},"page":"6157-6173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Antioxidant, anticancer, and anti\u2010inflammatory potential of Moringa seed and Moringa seed oil: A comprehensive approach"],"prefix":"10.1002","volume":"12","author":[{"given":"Muhammad","family":"Shahbaz","sequence":"first","affiliation":[{"name":"Department of Food Science and Technology Muhammad Nawaz Shareef University of Agriculture Multan  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hammad","family":"Naeem","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Muhammad Nawaz Shareef University of Agriculture Multan  Multan Pakistan"},{"name":"Food Technology Section, Post\u2010Harvest Research Centre Ayub Agricultural Research Institute  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Batool","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Muhammad Nawaz Shareef University of Agriculture Multan  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Imran","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology University of Narowal  Narowal Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzzamal","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Food Sciences Government College University Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Mujtaba","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Faculty of Engineering and Technology Hamdard University Islamabad Campus  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suliman A.","family":"Alsagaby","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, College of Applied Medical Sciences Majmaah University  AL\u2010Majmaah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Al\u00a0Abdulmonem","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine Qassim University  Buraidah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed H.","family":"El\u2010Ghorab","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science Jouf University  Sakaka Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed M.","family":"Ghoneim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy AlMaarefa University  Ad Diriyah Saudi Arabia"},{"name":"Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed E.","family":"Shaker","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy Jouf University  Sakaka Saudi Arabia"},{"name":"Department of Pharmacology &amp; Toxicology, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Abdelgawad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy Jouf University  Sakaka Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1804-1770","authenticated-orcid":false,"given":"Entessar","family":"Al\u00a0Jbawi","sequence":"additional","affiliation":[{"name":"Syrian Arab Republic Ministry of Agriculture and Agrarian Reform  Damascus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2019.05.010"},{"issue":"11","key":"e_1_2_13_3_1","first-page":"4929","article-title":"Nano\u2010micelle of Moringa oleifera seed oil triggers mitochondrial cancer cell apoptosis","volume":"17","author":"Abd\u2010Rabou A. 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