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The potential of plant\u2010derived natural compounds as anticancer medicines has been assessed owing to their favorable attributes of few side effects and significant antitumor activity. Mangrove plants and their derived compounds have been scientifically shown to exhibit many significant beneficial biological activities, such as anti\u2010inflammatory, immunomodulatory, antioxidant, neuroprotective, cardioprotective, and hepatoprotective properties. This study summarized mangrove plants and their derived compounds as potential anticancer agents, with an emphasis on the underlying molecular mechanisms. To explore this, we gathered data on the preclinical (in vivo and in\u00a0vitro) anticancer effects of mangrove plants and their derived compounds from reputable literature spanning 2000 to 2023. We conducted thorough searches in various academic databases, including PubMed, ScienceDirect, Wiley Online, SpringerLink, Google Scholar, Scopus, and the Web of Science. The results demonstrated that mangrove plants and their derived compounds have promising anticancer properties in preclinical pharmacological test systems through various molecular mechanisms, including induction of oxidative stress and mitochondrial dysfunction, cytotoxicity, genotoxicity, cell cycle arrest, apoptosis, autophagy, antiproliferative, antimetastatic, and other miscellaneous actions. Upon thorough observation of the pertinent information, it is suggested that mangrove plants and their derived chemicals may serve as a potential lead in the development of novel drugs for cancer therapy.<\/jats:p>","DOI":"10.1002\/fsn3.4318","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T21:29:01Z","timestamp":1720646941000},"page":"6174-6205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Anticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0672-6581","authenticated-orcid":false,"given":"Raihan","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University  Gopalganj Bangladesh"},{"name":"Phytochemistry and Biodiversity Research Laboratory BioLuster Research Center  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-9720","authenticated-orcid":false,"given":"Md. 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