{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:59:09Z","timestamp":1789567149064,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016640","name":"Malayer University","doi-asserted-by":"publisher","award":["3\u20101\u20101\u20104616"],"award-info":[{"award-number":["3\u20101\u20101\u20104616"]}],"id":[{"id":"10.13039\/100016640","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The utilization of grape stems, a by\u2010product of the grape processing industry, as a source of valuable bioactive compounds, particularly polyphenols, has gained attention in recent years. This study aimed to investigate different eco\u2010friendly extraction methods for obtaining polyphenols from grape (<jats:italic>Vitis vinifera<\/jats:italic> cv. Bidaneh Sefid) stems, focusing on green solvents and innovative techniques. Four extraction methods were tested, involving the use of water and polyethylene glycol (PEG) as green solvents, along with maceration, microwave, ultrasound, and reduced\u2010pressure techniques. High\u2010performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC\u2013ESI\u2010MS\/MS) was used to characterize and quantify the bioactive compounds in the extracts. A total of 29 polyphenols, including phenolic acids, flavonoids, proanthocyanidins, and stilbenes, were detected. Among the four extraction methods tested, methods 1 (water\u2009+\u2009microwave\u2009+\u2009ultrasound\u2009+\u2009atmospheric pressure) and 2 (water\u2009+\u2009microwave\u2009+\u2009ultrasound\u2009+\u2009reduced pressure) were found to be the most effective. Our study demonstrated that using water and PEG as green solvents, combined with techniques like microwave, ultrasound, and reduced pressure, effectively extracted both hydrophobic and hydrophilic compounds from the grape stems. These findings suggest that further exploration of these methods could lead to the development of value\u2010added products from grape stems, emphasizing the significance of green extraction techniques for the recovery of polyphenols from winemaking by\u2010products.<\/jats:p>","DOI":"10.1002\/fsn3.4330","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T04:54:20Z","timestamp":1720587260000},"page":"6789-6798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Identification of polyphenol composition in grape (<i>Vitis vinifera<\/i> cv. Bidaneh Sefid) stem using green extraction methods and LC\u2013MS\/MS analysis"],"prefix":"10.1002","volume":"12","author":[{"given":"Shiva","family":"Beilankouhi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Drug Applied Research Center University of Medical Sciences  Tabriz Iran"},{"name":"Department of Environmental Science Research Institute for Grapes and Raisin (RIGR)  Hamedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2913-9682","authenticated-orcid":false,"given":"Amir","family":"Pourfarzad","sequence":"additional","affiliation":[{"name":"Faculty of Agricultural Sciences, Department of Food Science and Technology University of Guilan  Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1213-540X","authenticated-orcid":false,"given":"Babak","family":"Ghanbarzadeh","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Department of Food Science and Technology University of Tabriz  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousa","family":"Rasouli","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture and Natural Resources, Department of Horticultural Science Engineering Imam Khomeini International University  Qazvin Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Hamishekar","sequence":"additional","affiliation":[{"name":"Drug Applied Research Center University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"issue":"7","key":"e_1_2_10_2_1","first-page":"108","article-title":"Selected potential pharmaceutical and medical benefits of phenolic compounds: Recent advances","volume":"3","author":"Abd Elgadir M.","year":"2023","journal-title":"Functional Food Science"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr10102014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25143146"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-022-09831-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fuel.2022.126492"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781003195771"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano13050836"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sciaf.2023.e01585"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2024.116099"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO02927K"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4171"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13010100"},{"issue":"5","key":"e_1_2_10_14_1","first-page":"5918","article-title":"A review of procyanidin: Updates on current bioactivities and potential health benefits","volume":"12","author":"Dasiman R.","year":"2022","journal-title":"Biointerface Research in Applied Chemistry"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aninu.2021.11.011"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9080720"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081221"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.136660"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15040928"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.134603"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16050659"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuz071"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-022-02859-7"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2021.11.019"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2021.105625"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00291"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2020.106498"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-84436-3_18"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1515\/ijfe-2023-0177"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3FB00252G"},{"key":"e_1_2_10_31_1","doi-asserted-by":"crossref","unstructured":"Mitra S. Mitra M. Saha M. &Nandi D. K.(2022).Supplementation of quercetin nutraceutical ameliorates stress among female college students.","DOI":"10.22376\/ijpbs\/lpr.2022.12.2.L1-12"},{"key":"e_1_2_10_32_1","first-page":"5307","article-title":"A review on natural products as immune system modulators against infections","volume":"53","author":"Nassar S. A.","year":"2022","journal-title":"Journal of Pharmaceutical Negative Results"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6904"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2022.116070"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14091856"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12030371"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026622666220623114450"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104894"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2023.106646"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2022.109492"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2020.123771"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2021.05.002"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032019"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25225243"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094628"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2019.1653867"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.4330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T13:14:14Z","timestamp":1731590054000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.4330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,9]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/fsn3.4330"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.4330","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,9]]},"assertion":[{"value":"2024-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}