{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:00:57Z","timestamp":1792155657963,"version":"4.4.0"},"reference-count":90,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Tragopogon coelesyriacus<\/jats:italic> is a pharmacotherapeutic herbaceous plant belonging to the Asteraceae family and consumed as a vegetable. Here, the methanolic and water extracts of <jats:italic>T. coelesyriacus<\/jats:italic> were obtained from its aboveground parts (stem, leaves, and flowers), and the phytochemical potentials were investigated by LC\u2010HRMS (liquid chromatography\u2013high resolution mass spectrometry) analysis for the first time. The antibacterial, antifungal, and anticarcinogenic activities of <jats:italic>T. coelesyriacus<\/jats:italic> extracts were investigated using experimental and in silico methods. <jats:italic>T. coelesyriacus<\/jats:italic> methanol extract revealed remarkable inhibitory activity against <jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, and <jats:italic>Klebsiella pneumonia<\/jats:italic> (MICs\u2009=\u20090.83, 1.67, and 1.67\u2009mg\/mL, respectively) compared to <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Enterobacter aerogenes<\/jats:italic> (MIC\u2009=\u200953.3\u2009mg\/mL). Inhibitory effects of <jats:italic>T. coelesyriacus<\/jats:italic> methanolic extracts were also observed in all <jats:italic>Candida<\/jats:italic> species tested, with the highest inhibition on <jats:italic>Candida krusei<\/jats:italic> (MIC\u2009=\u20090.83\u2009mg\/mL), whereas no inhibitory effect was identified from the water extract. Additionally, both <jats:italic>T. coelesyriacus<\/jats:italic> methanolic (IC50\u2009=\u200986\u2009\u03bcg\/mL) and water (IC50\u2009=\u200992\u2009\u03bcg\/mL) extracts revealed significant selective anticarcinogenic effects on AR42J pancreatic cancer cells. HeLa and MDA\u2010MB\u2010231 cells were, however, more resilient to methanol and water extract, respectively. In silico analyses further elucidated the noteworthy antibacterial potential of keracyanin chloride on <jats:italic>S. aureus<\/jats:italic> MurB enzyme and the remarkable inhibitory potential of naringin on FYN kinase specific for pancreatic cancer (AR42J) development. In conclusion, <jats:italic>T. coelesyriacus<\/jats:italic> phytochemicals with antibacterial, antifungal, and anticancer properties were revealed for the first time, and molecular docking studies on potential targets confirmed good agreement with experimental findings. Therefore, the current studies on <jats:italic>T. coelesyriacus<\/jats:italic> provide the basis for investigating new pharmaceutical potentials of other <jats:italic>Tragopogon<\/jats:italic> members.<\/jats:p>","DOI":"10.1002\/fsn3.4341","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T08:19:57Z","timestamp":1721204397000},"page":"7252-7272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Elucidating the antimicrobial and anticarcinogenic potential of methanolic and water extracts of edible <i>Tragopogon coelesyriacus<\/i> Boiss."],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8655-2716","authenticated-orcid":false,"given":"Tuba","family":"Unver","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Faculty of Pharmacy Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-3730","authenticated-orcid":false,"given":"Ugur","family":"Uzuner","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Karadeniz Technical University  Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9558-7048","authenticated-orcid":false,"given":"Selcen","family":"Celik\u2010Uzuner","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Karadeniz Technical University  Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-2447","authenticated-orcid":false,"given":"Ismet","family":"Gurhan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7527-6307","authenticated-orcid":false,"given":"Nur Sena","family":"Sivri","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Karadeniz Technical University  Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4559-2305","authenticated-orcid":false,"given":"Zeynep","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112466"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.133902"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935\u2010015\u20100221\u20101"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbspro.2011.05.195"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.777576"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S173867"},{"issue":"3","key":"e_1_2_10_8_1","first-page":"377","article-title":"Evaluation of antioxidant properties of some Tragopogon species growing in Turkey","volume":"10","author":"Bahad\u0131r Ac\u0131kara \u00d6.","year":"2013","journal-title":"Turkish Journal of Pharmaceutical Sciences"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.15237\/gida.GD22104"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.08.002"},{"key":"e_1_2_10_11_1","volume-title":"Anadolu da\u011flar\u0131nda 50 y\u0131l: Bir bitki avc\u0131s\u0131n\u0131n g\u00f6zlemleri","author":"Baytop T.","year":"2000"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1420\u20109101.2012.02616.x"},{"key":"e_1_2_10_13_1","volume-title":"Jawetz, Melnick, and Adelberg's Medical Microbiology","author":"Brooks G. 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