{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:59:00Z","timestamp":1787237940335,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Pueraria lobata<\/jats:italic>\n                    root and\n                    <jats:italic>Glycine max<\/jats:italic>\n                    (\n                    <jats:italic>L.<\/jats:italic>\n                    ) Merrill are rich in phytoestrogens. However, these bioactive ingredients have limited bioavailability due to their high molecular weight. In this study, we extracted two natural products and fermented with\n                    <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                    before mixing the fermented extracts (FPE\u2010FGE). To understand whether FPE\u2010FGE could alleviate menopause with dyslipidemia, we examined their effects on ovariectomy (OVX)\u2010induced dyslipidemia in mice. Oral administration of the FPE\u2010FGE (1:9, 3:7, and 9:1) did not affect safety\u2010related biomarkers, such as uterus index (%), vagina index (%), aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, and creatinine. Furthermore, FPE\u2010FGE (1:9, 3:7, and 9:1) increased the levels of 17\u03b2\u2010estradiol (E2) and expression of uterus estrogen receptor \u03b2 (ER\u03b2); there was little effect on the expression of uterus estrogen receptor \u03b1 (ER\u03b1), and reduced the levels of gonadotropins, such as luteinizing hormone (LH) and follicle\u2010stimulating hormone (FSH). However, only the FPE\u2010FGE (3:7) reduced the levels of blood lipids, including total cholesterol (TC) and LDL\u2010cholesterol (LDL\u2010C). Accordingly, FPE\u2010FGE (3:7) upregulated endothelial nitric oxide synthase (eNOS), nitric oxide (NO), cyclic guanosine monophosphate (cGMP), and protein kinase G (PKG). In conclusion, FPE\u2010FGE (3:7) attenuated the\u00a0menopausal dyslipidemia by upregulating eNOS\u2010NO\u2010cGMP signaling pathway.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.4356","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T12:53:07Z","timestamp":1722257587000},"page":"7544-7551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti\u2010dyslipidemic effects of\n                    <i>Pueraria lobata<\/i>\n                    root and\n                    <i>Glycine max<\/i>\n                    (\n                    <i>L<\/i>\n                    .) Merrill extracts fermented with\n                    <i>Lactiplantibacillus plantarum<\/i>\n                    in ovariectomized mice"],"prefix":"10.1002","volume":"12","author":[{"given":"Hyo\u2010Min","family":"Jang","sequence":"first","affiliation":[{"name":"The 2nd Research Institute CMG Pharmaceutical Co., Ltd.  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimyeong","family":"Ha","sequence":"additional","affiliation":[{"name":"Center for Consumer Health 1 Research CHA Advanced Research Institute  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6433-5392","authenticated-orcid":false,"given":"Insuk","family":"Choi","sequence":"additional","affiliation":[{"name":"The 2nd Research Institute CMG Pharmaceutical Co., Ltd.  Seongnam Korea"},{"name":"Center for Consumer Health 1 Research CHA Advanced Research Institute  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC\u201021\u20100537"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2015.01.016"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704534"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053319"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e31821adb43"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102672.2009.04648.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115705"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.20463\/jenb.2018.0018"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201076985\u20104"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.307547"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2023.105776"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu053"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1075"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4fo00133h"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.4.H1906"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029498\u20109"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1000613"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201007768\u20107"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2019.106582"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2019.04.008"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.12938\/bmfh.2015\u2010011"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.4228"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100031\u20101299597"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014\u20105793(99)00307\u20105"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.09.038"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009\u20102108"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/09637480701669463"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010019\u20101359\u20109"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015\u20102724"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8994-2_29"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.4.1148"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000007042"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.23812\/19\u201064A"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.10.008"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001753"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749\u20108546\u20106\u201041"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.4356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T17:16:57Z","timestamp":1744478217000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.4356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/fsn3.4356"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.4356","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,29]]},"assertion":[{"value":"2024-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}