{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T22:33:50Z","timestamp":1780439630124,"version":"3.54.1"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bisphenol A, a traditional endocrine disruptor, has been implicated in male infertility. This study investigated the effect of <jats:italic>Cucumeropsis mannii<\/jats:italic> seed oil (CMSO) on bisphenol A (BPA)\u2010induced biochemical toxicity in the testicular mitochondria of male albino rats. The rats were assigned randomly to six experimental groups (<jats:italic>n<\/jats:italic>\u2009=\u20096), A, B, C, D, E, and F. Group A received 1\u2009mL of olive oil. Groups B and C received 100\u2009mL\/kg body weight (BW) of BPA and 7.5\u2009mL\/kg BW CMSO, respectively. Rats in groups D, E, and F received preadministered doses of 100\u2009mL\/kg BW of BPA, 5\u2009mL\/kg BW of BPA, and 2.5\u2009mL\/kg BW of CMSO, respectively, followed by 6\u2009weeks of exposure to those doses. Some mitochondrial enzymes, mitochondrial membrane potential (MMP), mitochondria testicular protein, and body weight of rats were determined using standard methods. BPA significantly reduced succinate dehydrogenase, malate dehydrogenase, isocitrate dehydrogenase, NADH dehydrogenase, and monoamine oxidase activity. Also, BPA prominently decreased the MMP, mitochondrial testicular protein, and body weight of rats. Interestingly, coadministration of BPA and CMSO restored the dysregulated activities of the enzymes and levels of other biomarkers. We postulated that CMSO may be a promising drug for treating systemic toxicity caused by environmental toxicants such as BPA.<\/jats:p>","DOI":"10.1002\/fsn3.4379","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T06:50:00Z","timestamp":1723618200000},"page":"7854-7863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Cucumeropsis mannii<\/i> seed oil (<scp>CMSO<\/scp>) restores testicular mitochondrial dysfunctions by modulating the activities of dysregulated testicular mitochondrial enzymes in male albino rats exposed to bisphenol A"],"prefix":"10.1002","volume":"12","author":[{"given":"H. A.","family":"Ogwoni","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Science Ebonyi State University  Abakaliki Nigeria"},{"name":"Department of Medical Biochemistry, Faculty of Basic Medical Sciences Cross River University of Technology (CRUTECH)  Calabar Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7805-9027","authenticated-orcid":false,"given":"P. 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