{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:54:07Z","timestamp":1792518847062,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T00:00:00Z","timestamp":1724544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertension significantly impacts the survival and quality of life of animals, often leading to chronic kidney failure. Current clinical drugs used to manage hypertension carry the risk of causing adverse reactions. In contrast, certain natural peptides have demonstrated the ability to safely reduce blood pressure by inhibiting the production of angiotensin. We administered four biologically active peptide solutions to spontaneously hypertensive rats: derived from corn, wheat, egg white, and soybean. The efficacy of these peptides in reducing blood pressure was assessed through regular measurements of systolic pressure. Additionally, we analyzed levels of angiotensin\u2010converting enzyme and angiotensin 2 using immunohistochemistry and ELISA in\u00a0vivo. The indicators of oxidative stress and inflammation in hypertensive rats were evaluated using qRT\u2010PCR and ELISA, respectively. Both wheat (from 182.5\u2009\u00b1\u200912.26\u2009mmHg at day 0 to 168.86\u2009\u00b1\u20095.86\u2009mmHg at day 20, <jats:italic>p<\/jats:italic>\u2009=\u2009.0435) and soybean (from 189\u2009\u00b1\u20092.19\u2009mmHg at day 0 to 178.25\u2009\u00b1\u20095.14\u2009mmHg at day 20, <jats:italic>p<\/jats:italic>\u2009=\u2009.0017) notably lowered systolic blood pressure compared to their starting systolic blood pressures in spontaneously hypertensive rats. Both wheat and soybean peptides significantly reduced plasma ANG II levels, akin to captopril\u2019s effect. Wheat peptides additionally exhibited antioxidant properties. Only the corn peptide showed a significant increase in transcript levels of the proinflammatory factors IL\u20106 and TNF\u2010\u03b1. At the protein level, all four kinds of peptides significantly elevated IL\u20106 levels while inhibiting TNF\u2010\u03b1 secretion. This study demonstrates that wheat peptides and soybean peptides administered as dietary supplements exhibit significant hypotensive and antioxidant effects.<\/jats:p>","DOI":"10.1002\/fsn3.4404","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T04:40:34Z","timestamp":1724647234000},"page":"8200-8210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Antihypertensive and antioxidant effects of food\u2010derived bioactive peptides in spontaneously hypertensive rats"],"prefix":"10.1002","volume":"12","author":[{"given":"Yuefan","family":"Zhou","sequence":"first","affiliation":[{"name":"Nourse Centre for Pet Nutrition  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Xu","sequence":"additional","affiliation":[{"name":"Nourse Centre for Pet Nutrition  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongguan","family":"Tian","sequence":"additional","affiliation":[{"name":"Nourse Centre for Pet Nutrition  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7443-2169","authenticated-orcid":false,"given":"Yanping","family":"Xu","sequence":"additional","affiliation":[{"name":"Nourse Centre for Pet Nutrition  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,25]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","first-page":"158","article-title":"Inflammation, immunity, and hypertension","volume":"49","author":"Agita A.","year":"2017","journal-title":"Acta Medica Indonesiana"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5276130"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)32994-4"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318061"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.19590"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10091211"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)01330\u20101"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.31.030169.001223"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408390701425615"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318063"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/11.suppl_e.100"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa336"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134777"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2019.04.015"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy112"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906\u2010018\u20100903\u2010x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods9070932"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303697"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.01.058"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422413000206"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112353"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5582245"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010263"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.439"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101867"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427\u2010023\u20102336\u20101"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biochem\u2010061516\u2010045037"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.01.162"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001845"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11101406"},{"issue":"10","key":"e_1_2_12_32_1","first-page":"682","article-title":"Effect of corn peptide on alcohol metabolism and plasma free amino acid concentrations in healthy men","volume":"50","author":"Yamaguchi M.","year":"1996","journal-title":"European Journal of Clinical Nutrition"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.136389"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.7762"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14061229"}],"container-title":["Food Science &amp; 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