{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:46:32Z","timestamp":1782791192554,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T00:00:00Z","timestamp":1723334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004006","name":"Bilimsel Ara\u015ftirma Projeleri Birimi, Istanbul \u00dcniversitesi","doi-asserted-by":"publisher","award":["FLO\u20102022\u201039584"],"award-info":[{"award-number":["FLO\u20102022\u201039584"]}],"id":[{"id":"10.13039\/501100004006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Monosodium glutamate (MSG) is a flavor\u2010enhancing compound used to elevate the flavor profiles of various foods. This flavor enhancer is the sodium salt of L\u2010glutamic acid and is widely used in foods, such as flavorings, seasonings, sauces, and instant soups. The potential health effects of MSG consumption, particularly the health issues that excessive consumption could lead to, have been the focus of social concerns. It is stated that excessive consumption of MSG can cause cardiovascular diseases, obesity and diabetes, kidney damage, hypertension, anxiety, and memory impairment. The maximum permissible amount of MSG in foods is set at 10\u2009g\/kg according to the Turkish Food Codex. The aim of this study is to develop an appropriate method for analyzing the MSG content within the various food samples like flavorings, seasonings, and spices sold in Turkish local markets. The validation parameters of the developed method were examined and it was found that the developed method corresponds to the recommended values. The limit of detection and the limit of quantitation values were calculated as 4.78\u2009ng\/mL and 15.93\u2009ng\/mL, respectively. Recovery % was determined to be 100.96% in intra\u2010day and 132.22% in inter\u2010day analyses for the precision of the method. The results compared to the values specified in the Turkish Food Codex Food Additives Regulation and samples that purportedly did not contain MSG on their labels were found to contain MSG.<\/jats:p>","DOI":"10.1002\/fsn3.4406","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T03:53:45Z","timestamp":1723434825000},"page":"7806-7813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Investigation of monosodium glutamate content in flavors, seasonings, and sauces from local markets in Turkey"],"prefix":"10.1002","volume":"12","author":[{"given":"Yusuf","family":"Katranc\u0131","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleyna","family":"Aydemir","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beray","family":"K\u0131z\u0131lkaya","sequence":"additional","affiliation":[{"name":"Programme of Molecular Biotechnology and Genetics Institute of Graduate Studies in Sciences, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizem Y\u0131ld\u0131r\u0131m","family":"Ba\u015ftemur","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9778-2034","authenticated-orcid":false,"given":"Sabriye Percin","family":"Ozkorucuklu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,11]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"36","article-title":"Food: Its preservatives, additives and applications","volume":"1","author":"Abdulmumeen H. A.","year":"2012","journal-title":"International Journal of Chemical And Biochemical Sciences"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202300750"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA17885A"},{"key":"e_1_2_10_5_1","first-page":"219","article-title":"Effect of monosodium glutamate on hematological parameters in wistar rats","volume":"3","author":"Ashaolu J. O.","year":"2011","journal-title":"International Journal of Medicine and Medical Sciences"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2016.02.021"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ed081p347"},{"key":"e_1_2_10_8_1","first-page":"198","article-title":"Assessment of monosodium glutamate in some meat products","volume":"40","author":"Ayad A. E.","year":"2021","journal-title":"Benha Veterinary Medical Journal"},{"key":"e_1_2_10_9_1","first-page":"149","article-title":"Monosodium glutamate: Review on preclinical and clinical reports","volume":"13","author":"Bayram H. M.","year":"2023","journal-title":"Biointerface Research in Applied Chemistry"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2022.11.009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2017.12.033"},{"key":"e_1_2_10_12_1","first-page":"1","article-title":"European Parliament, Council of the European Union No 95\/2\/EC","volume":"61","author":"Directive","year":"1995","journal-title":"The Official Journal of the European Community L"},{"key":"e_1_2_10_13_1","first-page":"18","article-title":"Effects of umami substances monosodium glutamate (MSG) and ribonucleotides (GMP\/IMP) on mitotic index in Allium cepa L. plant","volume":"8","author":"Duran N.","year":"2017","journal-title":"Annals of Biological Research"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/19393210.2014.991355"},{"key":"e_1_2_10_15_1","first-page":"193","article-title":"Food additives and effects on the human health","volume":"32","author":"Erden \u00c7al\u0131\u015f\u0131r Z.","year":"2003","journal-title":"Journal of Faculty of Pharmacy of Ankara University"},{"key":"e_1_2_10_16_1","first-page":"36582","article-title":"U.S. Food and Drug Administration, U.S. Department of Health and Human Services","volume":"60","author":"FDA","year":"1995","journal-title":"Background"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoacint\/qsac053"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694-020-00768-8"},{"key":"e_1_2_10_19_1","unstructured":"ICH Harmonised Tripartite Guideline(1996).Validation of Analytical Procedures: Methodology: ICH Topics Q2B CPMP\/ICH\/281\/95 1\u201015."},{"key":"e_1_2_10_20_1","unstructured":"ICH Harmonised Tripartite Guideline(2005).Validation of Analytical Procedures: Text and Methodology Q2(R1). International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use Geneva 1\u201013."},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/27.9.847"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10895-023-03143-0"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e19675"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.13113\/CEDRUS.201833","article-title":"Antik\u00e7a\u011fda G\u0131dalar\u0131n Korunmas\u0131","volume":"6","author":"K\u00f6kmen Seyirci H.","year":"2018","journal-title":"Cedrus"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-1483.66795"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196804042781419"},{"key":"e_1_2_10_27_1","article-title":"Estimation of monosodium glutamate by modified HPLC method in various Pakistani spices formula","volume":"34","author":"Lateef M.","year":"2012","journal-title":"Journal of the Chemical Society of Pakistan"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12653"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.16685"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/227611a0"},{"key":"e_1_2_10_31_1","article-title":"Re\u2010evaluation of glutamic acid (E\u2009620), sodium glutamate (E\u2009621), potassium glutamate (E\u2009622), calcium glutamate (E\u2009623), ammonium glutamate (E\u2009624) and magnesium glutamate (E\u2009625) as food additives","volume":"15","author":"Mortensen A.","year":"2017","journal-title":"EFSA Journal"},{"key":"e_1_2_10_32_1","first-page":"1","article-title":"Mini review about monosodium glutamate","volume":"77","author":"Nguyen Thuy L.","year":"2020","journal-title":"Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj\u2010Napoca\u2010Food Science and Technology"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(01)01326-5"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2007.03.034"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2012.714008"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196805162782014"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijfs.14661"},{"key":"e_1_2_10_38_1","first-page":"760","article-title":"Method validation and rapid determination of monosodium glutamate in various food products by HPLC\u2010fluorescence detection and method optimization of HPLC\u2010evaporative light scattering detection approach without derivatization","volume":"60","author":"Soyseven M.","year":"2022","journal-title":"Journal of Chromatographic Science"},{"key":"e_1_2_10_39_1","unstructured":"Turkish Food Codex Food Additives Regulation. (2013)Official Gazette 28693."},{"key":"e_1_2_10_40_1","first-page":"107","article-title":"Maternal monosodium glutamate intake influences the learning ability of the offspring of Sprague Dawley rats","volume":"56","author":"\u00dcn \u0130.","year":"2018","journal-title":"Acta Pharm. Sci"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1939264"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.14834"},{"key":"e_1_2_10_43_1","first-page":"1","article-title":"Evaluation of certain food additives and contaminants. Thirty\u2010first report of the Joint FAO\/WHO Expert Committee on Food Additives","volume":"759","author":"WHO","year":"1987","journal-title":"World Health Organization Technical Report Series"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41538-023-00178-2"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.4406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T21:14:45Z","timestamp":1744492485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.4406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,11]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/fsn3.4406"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.4406","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,11]]},"assertion":[{"value":"2024-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}