{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:40:52Z","timestamp":1789641652513,"version":"4.0.0"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Five Australian seaweed species,\n                    <jats:italic>Phyllosphora comosa<\/jats:italic>\n                    ,\n                    <jats:italic>Ecklonia radiata<\/jats:italic>\n                    ,\n                    <jats:italic>Durvillaea potatorum<\/jats:italic>\n                    ,\n                    <jats:italic>Sargassum fallax<\/jats:italic>\n                    , and\n                    <jats:italic>Cystophora siliquosa<\/jats:italic>\n                    , thrive along the country's shorelines. Some of these seaweeds have recognized health benefits but have not been fully investigated in terms of their bioactive components and mechanisms of action. We employed ultrasonication with 70% methanol to extract phenolic compounds from these seaweeds and investigated a range of bioactivities for these extracts, including anti\u2010inflammatory activity exploring urease inhibition, nitric oxide scavenging activity, protein denaturation inhibition, and protease inhibition. Anti\u2010diabetic activities were investigated using \u03b1\u2010amylase and \u03b1\u2010glucosidase inhibition assays. Anti\u2010proliferative and anti\u2010mitotic activities were evaluated using yeast\u2010cell and green\u2010gram models, respectively. Our findings showed that\n                    <jats:italic>C.\u2009siliquosa<\/jats:italic>\n                    inhibited nitric oxide, urease, and protease activities, with\n                    <jats:italic>S.\u2009fallax<\/jats:italic>\n                    ,\n                    <jats:italic>P.\u2009comosa<\/jats:italic>\n                    , and\n                    <jats:italic>E.\u2009radiata<\/jats:italic>\n                    exhibiting substantial inhibition of protein denaturation.\n                    <jats:italic>E.\u2009radiata<\/jats:italic>\n                    displayed inhibitory effects on both \u03b1\u2010amylase and \u03b1\u2010glucosidase, whereas\n                    <jats:italic>P.\u2009comosa<\/jats:italic>\n                    targeted only the \u03b1\u2010glucosidase enzyme, indicating different mechanisms of anti\u2010diabetic activity. In these anti\u2010mitotic assays,\n                    <jats:italic>C.\u2009siliquosa<\/jats:italic>\n                    exhibited low cell viability and a significant anti\u2010proliferative effect, particularly within 24\u2009h, while\n                    <jats:italic>E.\u2009radiata<\/jats:italic>\n                    demonstrated notable inhibition at 48\u2009h. LC\u2010ESI\u2010QTOF\u2010MS\/MS investigation identified 48 phenolic compounds, including 19 phenolic acids, 20 flavonoids, and 9 other polyphenols. The presence of these compounds in extracts correlated with observed biological activities. These results support the potential health benefits of these seaweeds and link this activity to the presence of bioactive phenolics.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.4415","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T02:31:04Z","timestamp":1726453864000},"page":"8956-8967","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Insights into the in\u00a0vitro biological properties of Australian beach\u2010cast brown seaweed phenolics"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0358-0807","authenticated-orcid":false,"given":"Vigasini","family":"Subbiah","sequence":"first","affiliation":[{"name":"Centre for Sustainable Bioproducts Deakin University  Waurn Ponds Victoria Australia"},{"name":"School of Agriculture, Food and Ecosystem Sciences, Faculty of Science The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"School of Agriculture, Food and Ecosystem Sciences, Faculty of Science The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Duan","sequence":"additional","affiliation":[{"name":"School of Agriculture, Food and Ecosystem Sciences, Faculty of Science The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1676-2443","authenticated-orcid":false,"given":"Osman Tuncay","family":"Agar","sequence":"additional","affiliation":[{"name":"School of Agriculture, Food and Ecosystem Sciences, Faculty of Science The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin J.","family":"Barrow","sequence":"additional","affiliation":[{"name":"Centre for Sustainable Bioproducts Deakin University  Waurn Ponds Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2450-0830","authenticated-orcid":false,"given":"Hafiz A. R.","family":"Suleria","sequence":"additional","affiliation":[{"name":"Centre for Sustainable Bioproducts Deakin University  Waurn Ponds Victoria Australia"},{"name":"School of Agriculture, Food and Ecosystem Sciences, Faculty of Science The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,15]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"643","article-title":"Pharmacological activities of protocatechuic acid","volume":"72","author":"Abida Kalsoom Khan R. 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