{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:18:06Z","timestamp":1791559086326,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study investigates the hepatoprotective effects of olive oil and flaxseed oil on chemically induced hepatotoxicity in rats by evaluating key biochemical parameters, including free fatty acids, iodine value, liver enzymes (ALP, ALT, AST), cholesterol, triglycerides, and HDL levels. The results demonstrated significant improvements in these markers with the administration of olive oil and flaxseed oil, either individually or in combination. The free fatty acid percentages and iodine values were consistent with the known nutritional properties of the oils. Notably, the combination of olive oil and flaxseed oil yielded the most substantial benefits, reducing ALP (115.53\u2009\u00b1\u20090.44\u2009U\/L), ALT (50.77\u2009\u00b1\u20091.46\u2009U\/L), and AST (52.12\u2009\u00b1\u20090.36\u2009U\/L) levels while improving lipid profiles by lowering cholesterol (135.4\u2009\u00b1\u20091.43\u2009mg\/dL) and triglyceride levels (57.14\u2009\u00b1\u20092.35\u2009mg\/dL) and increasing HDL levels (49.20\u2009\u00b1\u20090.45\u2009mg\/dL). These findings suggest that olive oil and flaxseed oil, due to their antioxidant and anti\u2010inflammatory properties, can effectively mitigate liver damage and promote lipid metabolism. The study supports the potential therapeutic application of these oils in managing liver health and preventing hepatotoxicity.<\/jats:p>","DOI":"10.1002\/fsn3.4423","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T04:47:56Z","timestamp":1729658876000},"page":"9673-9681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative effect of olive oil and flaxseed oil on drug induced hepatotoxicity in rats"],"prefix":"10.1002","volume":"12","author":[{"given":"Waqas Ahmad","family":"Khan","sequence":"first","affiliation":[{"name":"National Institute of Food Science and Technology (NIFSAT), University of Agriculture  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Inam\u2010ur\u2010Raheem","sequence":"additional","affiliation":[{"name":"National Institute of Food Science and Technology (NIFSAT), University of Agriculture  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Rasheed","sequence":"additional","affiliation":[{"name":"National Institute of Food Science and Technology (NIFSAT), University of Agriculture  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Abdullah","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Food Science Government College University Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5340-4015","authenticated-orcid":false,"given":"Farhan","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Food Science Government College University Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9047-9075","authenticated-orcid":false,"given":"Muhammad","family":"Afzaal","sequence":"additional","affiliation":[{"name":"Department of Food Science Government College University Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiyaz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences, College of Applied Medical Sciences Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2100-6212","authenticated-orcid":false,"given":"Noor","family":"Akram","sequence":"additional","affiliation":[{"name":"Food Safety &amp; Biotechnology lab, Department of Food Science Government College University Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aasma","family":"Asghar","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Government College University Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7376-0700","authenticated-orcid":false,"given":"Gebremichael Gebremedhin","family":"Hailu","sequence":"additional","affiliation":[{"name":"Food Technology and Process Engineering Oda Bultum University  Chiro Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2018.1503947"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2019.1634544"},{"key":"e_1_2_12_4_1","first-page":"87","article-title":"Dietary flaxseed oil supplementation improves the oxidant\/antioxidant status in obese aged rats","volume":"3","author":"Ahlem L.","year":"2013","journal-title":"International Journal of Medicine and Pharmaceutical Sciences"},{"key":"e_1_2_12_5_1","first-page":"1158","article-title":"Hepatoprotective effect of flaxseed oil on hypercholesterolemia induced hepatotoxicity","volume":"11","author":"Ahmad M. 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