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In this regard, dried cumin seeds were collected from four different locations (SaadatShahr (P1) and Sarvestan (P2) from Fars Province and Kashmar (P3) and Sabzevar (P4) from Khorasan), and their essential oils were isolated by Clevenger apparatus and evaluated using GC and GC\u2013MS. In addition, the hypnotic and antinociceptive activities of the cumin EO sample, which had the highest yield and quality, respectively, were assessed via the pentobarbital\u2010induced loss of righting test and acetic acid\u2010induced writhing test. Our results showed that the highest amount of EO was present in sample P4 (3.63%), followed by P3 (2.92%), P2 (2.69%), and P1 (2.31%). GC\u2013MS analysis revealed cuminaldehyde (21.31\u201333.60%), \u03b3\u2010terpinene (13.68\u201323.29%), p\u2010mentha\u20101,4\u2010dien\u20107\u2010al (14.44\u201320.84%), p\u2010mentha\u20101,3\u2010dien\u20107\u2010al (10.06\u201314.02%), \u03b2\u2010pinene (9.32\u201311.46%), and p\u2010cymene (3.16\u20137.89%) were the major constituents in all the populations. Generally, the results showed that the seeds harvested from areas with hotter and drier climates (P3 and P4) had higher EO yields and cuminaldehyde concentrations but had moderate amounts of \u03b3\u2010terpinene, \u03b2\u2010pinene, and p\u2010cymene. In addition, the hypnotic (100 and 200\u2009mg\/kg) and antinociceptive (25, 50, and 100\u2009mg\/kg) effects of cumin EO were proven in animal models.<\/jats:p>","DOI":"10.1002\/fsn3.4432","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:24:33Z","timestamp":1726705473000},"page":"9025-9034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Phytochemical composition, hypnotic activity, and antinociceptive properties of cumin essential oil collected from various geographical regions"],"prefix":"10.1002","volume":"12","author":[{"given":"Abdorahim","family":"Nouri","sequence":"first","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansour","family":"Mofasseri","sequence":"additional","affiliation":[{"name":"School of Chemistry Tehran University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Jahani","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Pharmacology, School of Pharmacy Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masood","family":"Ghodrati","sequence":"additional","affiliation":[{"name":"Department of Horticultural Science, Faculty of Agriculture Tarbiat Modares University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Mohammad Mahdi","family":"Emam","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-7367","authenticated-orcid":false,"given":"Mohammad\u2010Taghi","family":"Ebadi","sequence":"additional","affiliation":[{"name":"Department of Horticultural Science, Faculty of Agriculture Tarbiat Modares University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2019.1699866"},{"key":"e_1_2_10_3_1","volume-title":"Identification of essential oil components by gas chromatography\/mass spectrometry","author":"Adams R. 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