{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:16:21Z","timestamp":1787242581495,"version":"build-2736575974"},"reference-count":75,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sauerkraut\u2010derived lactic acid bacterial (LAB) strains have gained attention due to their potential health benefits. This study focuses on evaluating seven Sauerkraut\u2010derived RAMULAB strains isolated from sauerkraut, aiming to identify promising candidates for modulating \u03b1\u2010glucosidase (AG) and \u03b1\u2010amylase (AM) enzymatic functions. RAMULAB strains with remarkable probiotic potential can contribute to the digestive health and manage conditions like diabetes. Identifying robust candidates from sauerkraut, a fermented food, holds promise for natural and cost\u2010effective probiotic sources. The RAMULAB strains underwent extensive characterization, including identification through 16S ribosomal RNA (rRNA) sequencing. Their tolerance to harsh conditions, adherence properties, antimicrobial activity, antioxidant potential, and inhibition of AG and AM were assessed. In silico analyses explored their molecular interactions, particularly with hydroxycitric acid, a potential antidiabetic compound. Among the RAMULAB strains, RAMULAB48 emerged as a standout candidate. It displayed exceptional resilience to acidic bile (\u226597%), and simulated gastrointestinal conditions (\u226595%), highlighting its suitability for probiotic applications. RAMULAB48 exhibited robust adherence properties, including cell\u2010surface hydrophobicity (80%), autoaggregation (42%), coaggregation with pathogens (\u226533%), and adhesion to epithelial cells. Additionally, all seven isolates demonstrated gamma\u2010hemolysis and resistance to antibiotics (Kanamycin, Methicillin, and Vancomycin), while displaying strong antibacterial properties against foodborne pathogens. These RAMULAB strains also exhibited varying degrees of antioxidant activity, with RAMULAB48 displaying the highest potential (\u226541%). In terms of antidiabetic activity, cell\u2010free supernatant (CS) obtained from RAMULAB48 expressed the highest inhibition levels, notably inhibiting yeast AG by an impressive 59.55% and AM being by a remarkable 67.42%. RAMULAB48 produced organic acids, including hydroxycitric acid (28.024\u2009mg\/mL), which showed promising antidiabetic properties through in silico analyses, indicating favorable interactions with the target enzymes. This study identifies\n                    <jats:italic>Lacticaseibacillus paracasei<\/jats:italic>\n                    RAMULAB48, a Sauerkraut\u2010derived RAMULAB strain, as a promising probiotic candidate with exceptional tolerance, adherence properties, antimicrobial activity, antioxidant potential, and antidiabetic effects. The presence of hydroxycitric acid further underscores its potential in managing diabetes.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.4444","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T05:41:53Z","timestamp":1729662113000},"page":"9682-9701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sauerkraut\u2010derived\n                    <scp>LAB<\/scp>\n                    strains as potential probiotic candidates for modulating carbohydrate digestion attributing bacterial organic acid profiling to antidiabetic activity"],"prefix":"10.1002","volume":"12","author":[{"given":"Sujay S.","family":"Huligere","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Bioinformatics JSS Academy of Higher Education &amp; Research  Mysuru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandana","family":"Kumari\u00a0V.\u00a0B.","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioinformatics JSS Academy of Higher Education &amp; 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