{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:11:40Z","timestamp":1771373500706,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to evaluate the lipid\u2010lowering and plasma cholesteryl ester transfer protein(CETP) activity of\n                    <jats:italic>Centranthus longiflorus<\/jats:italic>\n                    (CL) and \u03b2\u2010Sitosterol(\u03b2S) following intraperitoneal administration of Triton\u2010WR 1339 (=Tyloxapol) (TWR) to male Wistar rats. Hyperlipidemia(HL) was developed by intraperitoneal injection of TWR. The animals were divided into main eight groups of six rats each. Rats were housed in separate cages and fed a standard diet for 7\u2009days. After 7\u2009days, ethanol extraction of CL plant, aqueous suspension of \u03b2S and anacetrapib was given to rats by oral gavage 1\u2009h before the triton injection. Blood samples were collected and used for the biochemical parameters analysis. Histopathological studies were also performed on liver tissue. In hyperlipidemic rats(HR), CL extract and \u03b2S reduced total cholesterol similarly. \u03b2S lowered low\u2010density lipoprotein(LDL\u2010C) more than CL extract. Both CL extract and \u03b2S approximated impaired Alanine transaminase(ALT) and Aspartate transaminase(AST) levels in HR's to the level of control. CL extract provided better protection than \u03b2S against deterioration in liver tissue samples seen in hyperlipidemic rats. Finally, CL extract and \u03b2S inhibited CETP, at which point \u03b2S was more effective. These findings showed that CL extract and \u03b2S reduce plasma lipid concentration and may have a hypolipidemic effect due to their anti\u2010CETP properties.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.4471","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T17:33:53Z","timestamp":1729791233000},"page":"9788-9798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessing lipid\u2010lowering and plasma cholesteryl ester transfer protein activity of\n                    <i>Centranthus longiflorus<\/i>\n                    and \u03b2\u2010Sitosterol following administration to triton\n                    <scp>WR1339<\/scp>\n                    \u2010 treated rats"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-9065","authenticated-orcid":false,"given":"Seda","family":"Askin","sequence":"first","affiliation":[{"name":"Health Services Vocational School Ataturk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma Zuhal","family":"Umudum","sequence":"additional","affiliation":[{"name":"Medicine Faculty Ataturk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"209","article-title":"Simultaneous determination of \u03b1\u2010amyrin and \u03b2\u2010sitosterol in Centranthus longiflorus Stev. 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