{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:42:48Z","timestamp":1786977768972,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T00:00:00Z","timestamp":1729382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T00:00:00Z","timestamp":1729382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["BiHauts Eco de France CPER\/FEDER 2021\u20102027 program"],"award-info":[{"award-number":["BiHauts Eco de France CPER\/FEDER 2021\u20102027 program"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In response to nutrients, intestinal L\u2010 and K\u2010cells naturally secrete glucagon\u2010like peptide 1 (GLP\u20101). GLP\u20101 regulates postprandial blood glucose by increasing insulin secretion, slowing down gastric emptying and inducing satiety. A selection of specifically developed collagen hydrolysates was screened for their ability to enhance natural GLP\u20101 production in\u00a0vitro. The best performing hydrolysate, H80 (Nextida GC), was orally administered at different doses to lean, normoglycemic mice and overweight, prediabetic mice. Lean mice were acutely challenged 45\u2009min before an oral glucose load. While daily supplemented for 6\u2009weeks, prediabetic mice were acutely challenged at day 21 and 34. Oral glucose tolerance, plasma insulin and GLP\u20101 levels were assessed, and a gastric emptying assay performed in prediabetic mice. H80 significantly lowered the blood glucose response in lean and prediabetic mice, at a 4\u2009g\/kg dose (\u221225% and \u221236%, respectively), compared to vehicle. In chronically supplemented, prediabetic mice, acute H80 administration slowed down gastric emptying (\u221260%) after 21\u2009days and increased plasma insulin (+166%) after 35\u2009days of supplementation. H80 increased plasma active GLP\u20101 in lean (+217%) and prediabetic (+860%) mice. Overall, the data indicate that the specific collagen hydrolysate, H80, has significant GLP\u20101\u2010mediated effects on oral glucose tolerance in lean and prediabetic mice. Furthermore, effects on postprandial glucose tolerance were evaluated in a small, human, proof of concept study. H80 reduced the postprandial glucose response at a 5\u2009g dose in healthy, normoglycemic and prediabetic participants. Oral supplementation with H80 might thus be a promising strategy to maintain normal glucose tolerance.<\/jats:p>","DOI":"10.1002\/fsn3.4538","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T02:50:54Z","timestamp":1729479054000},"page":"9607-9620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Specific Collagen Hydrolysate Improves Postprandial Glucose Tolerance in Normoglycemic and Prediabetic Mice and in a First Proof of Concept Study in Healthy, Normoglycemic and Prediabetic Humans"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3062-4733","authenticated-orcid":false,"given":"Estelle","family":"Grasset","sequence":"first","affiliation":[{"name":"Physiogenex SAS  Escalquens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Briand","sequence":"additional","affiliation":[{"name":"Physiogenex SAS  Escalquens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolina","family":"Virgilio","sequence":"additional","affiliation":[{"name":"Rousselot BV  Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Sch\u00f6n","sequence":"additional","affiliation":[{"name":"BioTeSys GmbH  Esslingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Natural and Economic Sciences Ulm University of Applied Sciences  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Cudennec","sequence":"additional","affiliation":[{"name":"UMRT BioEcoAgro 1158 Univ. 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