{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:14:00Z","timestamp":1775819640486,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010260","name":"Xiamen Southern Oceanographic Center","doi-asserted-by":"publisher","award":["21CZP002HJ05"],"award-info":[{"award-number":["21CZP002HJ05"]}],"id":[{"id":"10.13039\/501100010260","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    With the rapid emergence of pufferfish aquaculture and processing industries, fish skin is underutilized as a byproduct of processing, leading to resource waste. In this study,\n                    <jats:italic>Takifugu bimaculatus<\/jats:italic>\n                    skin collagen (TBSC) was extracted by acetic acid solubilization and its physicochemical properties were analyzed. The effects of TBSC and the TBSC hydrolysate (TBSCH) on ultraviolet (UV) irradiation\u2010induced photoaging were investigated using a mouse model. The purity of TBSC was 90.02%. Electrophoresis and Fourier infrared spectroscopy characterization of TBSC showed that the type of collagen in TBSC was typical standard type I. The degree of hydrolysis was selected to optimize the hydrolysis conditions for TBSC. The papain enzyme dosage, temperature, pH, and hydrolysis duration of 51,000\u2009U\/g, 48.03\u00b0C, 5.35, and 4\u2009h have been demonstrated to be the optimum hydrolysis conditions for TBSCH. Oral administration of either TBSC or TBSCH ameliorated UV\u2010induced skin erythema and hyperkeratosis. TBSC and TBSCH treatment increased collagen content and had an inhibitory effect on matrix metalloproteinase (MMP)\u20102 and MMP\u20103 expression, whereas MMP\u20109 expression was significantly reversed only in the TBSCH\u2010treated groups. The expression of the c\u2010Jun protein was much lower in these groups, suggesting that TBSCH had a greater alleviating effect on collagen degradation and extracellular matrix breakdown. Therefore, it is proposed that TBSCH has the potential to be used as a nutricosmetic agent with protective attributes against UV\u2010induced skin damage and concurrent collagen depletion.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.4559","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T05:33:24Z","timestamp":1732080804000},"page":"10605-10617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oral Intake of Collagen and Collagen Hydrolysate From\n                    <i>Takifugu bimaculatus<\/i>\n                    Attenuates Ultraviolet\u2010Induced Skin Photoaging in Mice"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9738-7568","authenticated-orcid":false,"given":"Bei","family":"Chen","sequence":"first","affiliation":[{"name":"School of Life Sciences Xiamen University  Xiamen China"},{"name":"Fisheries Research Institute of Fujian Key Laboratory of Cultivation and High\u2010Value Utilization of Marine Organisms in Fujian Province  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shurong","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Life Sciences Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuilin","family":"Cai","sequence":"additional","affiliation":[{"name":"Fisheries Research Institute of Fujian Key Laboratory of Cultivation and High\u2010Value Utilization of Marine Organisms in Fujian Province  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Qiao","sequence":"additional","affiliation":[{"name":"Fisheries Research Institute of Fujian Key Laboratory of 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Utilization of Marine Organisms in Fujian Province  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Liu","sequence":"additional","affiliation":[{"name":"Fisheries Research Institute of Fujian Key Laboratory of Cultivation and High\u2010Value Utilization of Marine Organisms in Fujian Province  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Fisheries Research Institute of Fujian Key Laboratory of Cultivation and High\u2010Value Utilization of Marine Organisms in Fujian Province  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Xiamen University  Xiamen 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