{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:40:19Z","timestamp":1773870019213,"version":"3.50.1"},"reference-count":64,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874403"],"award-info":[{"award-number":["81874403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Shenxian\u2013Shengmai (SXSM) is a Chinese patent medicine used in the treatment of sick sinus syndrome (SSS). However, its active chemical compounds and the underlying molecular mechanisms remain unclear. In this study, we researched the underlying mechanisms of SXSM in treating SSS. We conducted network analysis and molecular docking to identify the small molecules and core targets responsible for the therapeutic efficacy of SXSM on SSS. In\u00a0vitro experiments were performed to verify the potential therapeutic mechanism. Network pharmacological analysis identified 17 core targets. Among these, BMP4, KCNH2, KCNMA1, and KCNQ1 were identified to be involved in various biological processes, such as the formation and regulation of the cardiac pacemaking system and potassium ion transmembrane transport. The experimental analysis revealed that SXSM could upregulate the expression of the\n                    <jats:italic>Bmp4\/Tbx3\/Hcn4<\/jats:italic>\n                    pathway and the expression of\n                    <jats:italic>Kcnh2<\/jats:italic>\n                    ,\n                    <jats:italic>Kcnma1<\/jats:italic>\n                    , and\n                    <jats:italic>Kcnq1<\/jats:italic>\n                    channels, which protected and improved the pacemaking function of pacemaker cells (P cells) and increased the heart rate. These findings provide a scientific basis in the study of the mechanism of traditional Chinese medicine in the treatment of SSS.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.4587","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T07:13:45Z","timestamp":1731482025000},"page":"10517-10534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Potential Targets of Shenxian\u2013Shengmai Oral Liquid in Treating Sick Sinus Syndrome Based on Network Pharmacology and Molecular Docking"],"prefix":"10.1002","volume":"12","author":[{"given":"Ping","family":"Hou","sequence":"first","affiliation":[{"name":"Graduate School Liaoning University of Traditional Chinese Medicine  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Yu","family":"Min","sequence":"additional","affiliation":[{"name":"Experimental Center of Traditional Chinese Medicine Affiliated Hospital of Liaoning University of Traditional Chinese Medicine  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health Shenyang Medical College  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate School Liaoning University of Traditional Chinese Medicine  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Shenyang Medical College  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Ping","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of NHC Key Laboratory of Reproductive Health and Medical Genetics Liaoning Research Institute of Family Planning (The Affiliated Reproductive Hospital of China Medical University)  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010Jia","family":"Yao","sequence":"additional","affiliation":[{"name":"College of Life and Health Sciences Northeastern University  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling\u2010Kang","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate School Liaoning University of Traditional Chinese Medicine  Shenyang Liaoning 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