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Throughout the study, various parameters were meticulously evaluated, including serum levels of key reproductive hormones (testosterone (T), estradiol (E2), follicle\u2010stimulating hormone (FSH), luteinizing hormone (LH), and anti\u2010M\u00fcllerian hormone (AMH)), as well as monitoring alterations in the estrous cycle, follicle development, and ovulation rates. Additionally, markers of oxidative stress and inflammation were measured. Findings revealed that PCOS mice exhibited disordered estrous cycle, polycystic ovarian morphologies, abnormal serum reproductive hormones and lipid metabolism, heightened oxidative stress, and augmented inflammatory responses. Notably, upon administration of the combined astaxanthin and curcumin, PCOS mice exhibited significant improvements in their estrous cyclicity and ovarian histology. The treatment led to a significant reduction in serum total cholesterol (TC) levels and normalization of T, E2, FSH, LH, and AMH levels. Moreover, there was a marked decrease in the levels of serum reactive oxygen species (ROS) and malondialdehyde (MDA), indicating attenuation of oxidative stress. Concurrently, the activity of the antioxidant enzyme catalase (CAT) significantly increased, while proinflammatory cytokines interferon\u2010\u03b3 (IFN\u2010\u03b3) and interleukin\u20106 (IL\u20106) in the ovarian tissue were notably decreased. The combined treatment also resulted in a substantial increase in the number of ova and a significant decline in the rate of abnormal ova, with these therapeutic effects proving more effective compared to either astaxanthin or curcumin alone. In conclusion, the co\u2010administration of astaxanthin and curcumin demonstrated a remarkable effect in improving abnormal lipid metabolism and restoring reproductive endocrine functions in PCOS mice. Furthermore, it effectively mitigated systemic and local oxidative stress and chronic inflammatory injury, thereby promoting follicular growth and enhancing ovulatory function in the context of PCOS.<\/jats:p>","DOI":"10.1002\/fsn3.4597","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T06:42:22Z","timestamp":1732084942000},"page":"10618-10627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Synergistic Effect and Mechanism of Combined Astaxanthin and Curcumin Administration on Ovarian Function in\n                    <scp>PCOS<\/scp>\n                    Mice"],"prefix":"10.1002","volume":"12","author":[{"given":"Gao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Physiology, West China School of Basic Medical Sciences and Forensic Medicine Sichuan University  Chengdu 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