{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:39:27Z","timestamp":1773869967730,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011665","name":"Deanship of Scientific Research, King Saud University","doi-asserted-by":"publisher","award":["RSPD2024R566"],"award-info":[{"award-number":["RSPD2024R566"]}],"id":[{"id":"10.13039\/501100011665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Advance glycation end products (AGEs) are the main reason for diabetic complications. Persistent hyperglycemia and non\u2010enzymatic glycation increase the rate of AGEs formation. Natural functional food\u2010based approaches are mainly under investigation these days to discover new treatment options. We focused to investigate potential of medium polar fractions of\n                    <jats:italic>Citrus paradesi<\/jats:italic>\n                    . The peels fractions were analsyed for phytochemical profile, FTIR, HPLC\u2010DAD, and LCMS\u2010QTof, and biological investigation including antioxidant assays, \u03b1\u2010glucosidase inhibition, and Anti AGEs inhibition was performed. LCMS\u2010QTof confirmed the presence of flavonoids and polymethoxylated flavonoids including naringin, narirutin 4\u2010O\u2010glucoside, hesperidin, naringenin\u20107\u2010O\u2010rutinoside hexamethoxyflavone, 3,5,6,7,8,3\u2032,4\u2032 heptamethoxyflavone were major compounds. A significant antioxidant activity was recorded in case of chloroform fraction compared to ethyl acetate fraction. Similarly a substancial AGEs inhibition in oxidative mode (IC\n                    <jats:sub>50<\/jats:sub>\n                    0.23\u2009mg\/mL) and non\u2010oxidative mode (IC\n                    <jats:sub>50<\/jats:sub>\n                    0.10\u2009mg\/mL) was observed in chloroform fraction, whereas ethyl acetate fraction was only active in oxidative mode (IC\n                    <jats:sub>50<\/jats:sub>\n                    0.69\u2009mg\/mL). A moderate \u03b1\u2010glucosidase inhibition (IC\n                    <jats:sub>50<\/jats:sub>\n                    1.23\u2009mg\/mL) was noticed in total extract, while significant activity was recorded in chloroform fraction (IC\n                    <jats:sub>50<\/jats:sub>\n                    0.78\u2009mg\/mL). It was concluded that medium polar fraction of\n                    <jats:italic>C. paradesi<\/jats:italic>\n                    possesses antidiabetic and anti\u2010AGEs potential that can be due to presence of flavonoids and polymethoxylated flavonoids.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.4602","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T01:48:26Z","timestamp":1732240106000},"page":"10655-10665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Advance Glycation End Products Inhibition by\n                    <i>Citrus paradisi<\/i>\n                    Peel Extract; Characterization,\n                    <scp>LCMS<\/scp>\n                    \u2010\n                    <scp>QTOF<\/scp>\n                    Analysis, and Biological Evaluation"],"prefix":"10.1002","volume":"12","author":[{"given":"Muhammad Fakhar Ul","family":"Mehmood","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy University of Balochistan  Quetta Pakistan"},{"name":"NPRL, Department of Pharmacognosy, Faculty of Pharmacy Gomal University  Dera Ismail Khan Khyber Pakhtunkhwa Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Marvi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy University of Balochistan  Quetta Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatem A.","family":"Abuelizz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nighat","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Gomal Medical College  Dera Ismail Khan Khyber Pakhtunkhwa Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raheela","family":"Bano","sequence":"additional","affiliation":[{"name":"Department of Pathology Gomal Medical College  Dera Ismail Khan Khyber Pakhtunkhwa Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asif","family":"Wazir","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imran","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7343-078X","authenticated-orcid":false,"given":"Khizar","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Pathology Gomal Medical College  Dera Ismail Khan Khyber Pakhtunkhwa Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saiqa","family":"Ishtiaq","sequence":"additional","affiliation":[{"name":"Centre for Study of Human Health Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5562-6703","authenticated-orcid":false,"given":"Adnan","family":"Amin","sequence":"additional","affiliation":[{"name":"NPRL, Department of Pharmacognosy, Faculty of Pharmacy Gomal University  Dera Ismail Khan Khyber Pakhtunkhwa Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-018-3499-x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.06.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12111016"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.430"},{"key":"e_1_2_10_6_1","first-page":"1019","article-title":"Phytochemical Screening and Antioxidant Activities of Some Selected Medicinal Plants Used for Malaria Therapy in Southwestern Nigeria","volume":"7","author":"Ayoola G. 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