{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:13:27Z","timestamp":1787937207286,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In the Rutaceae family <jats:styled-content style=\"fixed-case\"><jats:italic>Citrus maxima<\/jats:italic><\/jats:styled-content> is the biggest among all fruits, tradtionally used for several purposes due to its diverse ethnomedicinal, phytochemical, and pharmacological activities. Different portions of this plant have been used as sedatives and anti\u2010inflammatory medications, as well as to treat coughs, fevers, asthma, diarrhea, ulcers, and diabetes. There is a scientific potential for the methanolic seed extract to contain bioactive compounds, similar to those found in other parts of the plant. The extract derived from the seeds has already demonstrated potential biological activity. Moreover, there weren't many in\u00a0vivo and in\u00a0vitro research works on these plants' seeds. Therefore, the current research work was undertaken to analyze anti\u2010diarrheal and antipyretic potentials of the methanolic extract of <jats:styled-content style=\"fixed-case\"><jats:italic>Citrus maxima<\/jats:italic><\/jats:styled-content> seeds (MCM). To evaluate MCM's effectiveness in treating diarrhea, castor oil\u2010induced diarrhea model was utilized as an evaluating method. The antipyretic effect in mice was measured using brewer's yeast induced pyrexia model. The MCM at 200 and 400\u2009mg\/kg doses markedly reduced hyperpyrexia, induced by yeast. The effect remained persistent up to 4th hour after administration. In the castor oil induced diarrhea model, the methanolic seed extract showed high level of dose dependent inhibition of diarrhea for 4\u2009h following castor oil administration. Further investigation is necessary to elucidate and clarify the specific causative agents responsible for the dose\u2010dependent effects observed. The findings of the present study suggest that MCM seed extract may represent a promising alternative for the development of innovative anti\u2010diarrheal and anti\u2010pyretic compounds.<\/jats:p>","DOI":"10.1002\/fsn3.4631","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T02:43:13Z","timestamp":1735612993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Investigation on Anti\u2010Diarrheal and Antipyretic Activities of <scp><i>citrus maxima<\/i><\/scp> Seeds in Swiss Albino Mice Model"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5726-2840","authenticated-orcid":false,"given":"Nazratun Noor","family":"Maria","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha Akter","family":"Jasmin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umme","family":"Tahmida","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6472-046X","authenticated-orcid":false,"given":"Saurav","family":"Singha","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanveer","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Chittagong  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40816-023-00354-7"},{"key":"e_1_2_10_3_1","first-page":"47","article-title":"Investigation of Anti\u2010Inflammatory, Antipyretic and Analgesic Effect of Yemeni Sidr Honey","volume":"80","author":"Alzubier A. 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