{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T14:36:50Z","timestamp":1758811010049,"version":"3.41.2"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The objective of this study was to investigate the effect of the <jats:styled-content style=\"fixed-case\"><jats:italic>Lactobacillus plantarum<\/jats:italic><\/jats:styled-content> (<jats:styled-content style=\"fixed-case\"><jats:italic>L. plantarum<\/jats:italic><\/jats:styled-content>) SS18\u201050 (an isolate with favorable probiotic properties following space traveling) on dextran sulfate sodium (DSS)\u2010induced colitis in mice. Male ICR mice were randomly assigned to one of six groups: a control group, a model group, and four intervention groups comprising the isolate (SS18\u201050\u2010L and SS18\u201050\u2010H) and the wild type (GS18\u2010L and GS18\u2010H) strains. The model group and the intervention groups were administered a 3.5% DSS (w\/v) solution to induce acute enteritis. The four intervention groups were administered the corresponding bacterial suspensions, SS18\u201050\u2010L (1.0\u2009\u00d7\u200910<jats:sup>7<\/jats:sup>\u2009CFU\/mL), SS18\u201050\u2010H (1.0\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\u2009CFU\/mL), GS18\u2010L (1.0\u2009\u00d7\u200910<jats:sup>7<\/jats:sup>\u2009CFU\/mL), and GS18\u2010H (1.0\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\u2009CFU\/mL). The results demonstrated that the disease activity index (DAI) score of the SS18\u201050\u2010H was markedly lower than that of the CON. Subsequently, the colon tissue of mice was analyzed to determine the levels of myeloperoxidase (MPO), superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA). The results demonstrated that all strains within the intervention groups exhibited good performance to prevent colitis. Particularly, the SS18\u201050\u2010H strain exhibited a pronounced stimulative effect on GSH, an increase in SOD activity, and a decrease in MPO activity and MDA content. The SS18\u201050\u2010H treatment resulted in a notable elevation in serum somatostatin (SS) levels and a concomitant reduction in endothelin (ET) and substance P (SP) levels, which approached normal ranges. The results of the RT\u2010qPCR analysis demonstrated that the mRNA expression levels of tumor necrosis factor (TNF\u2010\u03b1), cyclooxygenase (COX\u20102), interleukin (IL\u201010), and interleukin (IL\u20106) in the SS18\u201050\u2010H were significantly reduced to levels comparable to those observed in the CON. In conclusion, <jats:styled-content style=\"fixed-case\"><jats:italic>L. plantarum<\/jats:italic><\/jats:styled-content> SS18\u201050 has been demonstrated to inhibit the development of colitis in a dose\u2010dependent manner, thereby establishing it as a high\u2010quality lactic acid bacterium with a colitis inhibitory effect.<\/jats:p>","DOI":"10.1002\/fsn3.4657","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T03:38:22Z","timestamp":1733801902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Potential of the Probiotic Isolate <scp><i>Lactobacillus plantarum<\/i> SS18\u201050<\/scp> to Prevent Colitis in Mice"],"prefix":"10.1002","volume":"13","author":[{"given":"Dan","family":"Wang","sequence":"first","affiliation":[{"name":"Changchun Polytechnic  Changchun China"},{"name":"College of Food Science and Engineering Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-6160","authenticated-orcid":false,"given":"Tiehua","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7941-8050","authenticated-orcid":false,"given":"Luxin","family":"Qiu","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1882-7490","authenticated-orcid":false,"given":"Changhui","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13099\u2010019\u20100341\u20106"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002727\u2010200504000\u201000013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43211"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705941"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.05.007"},{"issue":"2","key":"e_1_2_9_7_1","first-page":"238","article-title":"Clinicopathologic Study of Dextran Sulfate Sodium Experimental Murine Colitis","volume":"69","author":"Cooper H. 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