{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T11:08:55Z","timestamp":1784372935767,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study evaluates the therapeutic impact of Fructus aurantii (FA) stir\u2010baked with tartary buckwheat bran (TBB) on functional dyspepsia (FD), employing a reserpine at the dose of 5\u2009mg\/kg to rats. FA, a traditional Chinese herbal medicine, is processed with TBB to enhance its gastrointestinal motility benefits. The study's objectives were to assess the impact of this preparation on intestinal flora, SCFA levels, and metabolomic profiles in FD. Rats were divided into groups receiving different treatments, with the TBB\u2010FA group showing a 7.15\u201333.2 times increase in fecal SCFA levels, specifically propionate and butyrate, compared to the Fructus aurantii (FA) stir\u2010baked with wheat bran (WB) group (WB\u2010FA) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Metabolomics identified 23 serum and 11 intestinal mucosal biomarkers associated with FD, predominantly linked to the purine metabolic pathway. Results indicated a significant positive correlation (<jats:italic>r<\/jats:italic>\u2009\u2265\u20090.7) between the abundance of Bacteroides and the expression of propionate and isobutyrate in fecal samples post\u2010TBB\u2010FA treatment. This suggests that TBB\u2010FA may enhance beneficial gut bacteria and SCFA production, potentially modulating the purinergic signaling pathway, which is implicated in gastrointestinal motility. In conclusion, the study demonstrates that TBB\u2010FA could be a promising therapeutic approach for FD by improving gut microbiota and SCFA levels and highlights the purinergic signaling pathway as a novel target for treatment. The findings pave the way for further research into the integration of traditional Chinese medicine and modern therapeutic strategies for FD.<\/jats:p>","DOI":"10.1002\/fsn3.4695","type":"journal-article","created":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T11:35:29Z","timestamp":1736681729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tartary Buckwheat Bran and Fructus Aurantii Combination (<scp>TBB<\/scp>\u2010<scp>FA<\/scp>): A Promising Therapeutic Approach for Functional Dyspepsia via Modulation of Gut Microbiota, Short\u2010Chain Fatty Acids and Purine Signaling Pathway"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9806-5475","authenticated-orcid":false,"given":"Di","family":"Wang","sequence":"first","affiliation":[{"name":"Southwest State Key Laboratory of Traditional Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Zeng","sequence":"additional","affiliation":[{"name":"Southwest State Key Laboratory of Traditional Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinge","family":"Wang","sequence":"additional","affiliation":[{"name":"Southwest State Key Laboratory of Traditional Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Wen","sequence":"additional","affiliation":[{"name":"Southwest State Key Laboratory of Traditional Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Southwest State Key Laboratory of Traditional Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7454-0873","authenticated-orcid":false,"given":"Shijun","family":"Xu","sequence":"additional","affiliation":[{"name":"Southwest State Key Laboratory of Traditional Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113627"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.131355"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-013-9395-y"},{"issue":"20","key":"e_1_2_10_5_1","first-page":"5397","article-title":"Research Progress of Signal Pathways Related to Functional Dyspepsia Treated by Traditional Chinese Medicine","volume":"48","author":"Chang Y.","year":"2023","journal-title":"Chinese Journal of Traditional Chinese Medicine"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc3621"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2020.1743673"},{"issue":"11","key":"e_1_2_10_8_1","first-page":"229","article-title":"Experimental Study on the Effect of WeitongXiaopi Prescription on the Expression of 5\u2010HT and Its Receptor in Rats With Functional Dyspepsia of Liver\u2010Qi and Spleen\u2010Deficiency","volume":"38","author":"Fan M. 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