{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:36:03Z","timestamp":1771338963255,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Polygonum plebeium<\/jats:italic><\/jats:styled-content>, a member of the Polygonaceae family, is commonly known as small knotweed and has been traditionally used to treat various ailments, including cough, gastrointestinal disorders, respiratory infections, liver disease, inflammation, dysentery, eczema and ringworms, and other skin conditions. Many studies have suggested that plants belonging to this genus possess strong cardio\u2010protective potentials. Rats were pre\u2010treated with crude methanolic extract and other fractions at a dose of 500\u2009mg\/kg followed by administration of Isoproterenol hydrochloride after 24\u2009h for 2\u2009days. The cardioprotective effect was determined by investigating the levels of Biomarkers responsible for myocardial infarction (MI). Among all fractions Pp.CF (chloroform fraction) exhibited a significant cardioprotective effect by decreasing the levels of ALT, AST, CPK, and LDH to 74.56\u2009\u00b1\u20091.45, 95.78\u2009\u00b1\u20092.75, 156.73\u2009\u00b1\u20091.84, and 215.55\u2009\u00b1\u20095.33\u2009IU\/L in serum. The same fraction was tested for cardio\u2010protective potential at a dose of 50, 100, and 250\u2009mg\/kg. Pp.CF at a dose of 250\u2009mg\/kg exhibited prominent effects and reduced levels of biomarkers responsible for MI. Further investigations confirmed that Pp.CF possesses antihyperlipidemic, membrane stabilizing, and thrombolytic potential which suggests <jats:styled-content style=\"fixed-case\"><jats:italic>P. plebeium<\/jats:italic><\/jats:styled-content> an ideal candidate for natural product isolation which will be helpful in the management of cardiovascular problems.<\/jats:p>","DOI":"10.1002\/fsn3.4750","type":"journal-article","created":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T13:55:26Z","timestamp":1736690126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Insight Into the Phytochemical Composition, Cardioprotective, and Antioxidant Characteristics of Small Knotweed (<i>Polygonum plebeium<\/i> R. Br.) Extract and Its Derived Fractions"],"prefix":"10.1002","volume":"13","author":[{"given":"Muhammad","family":"Ibrar","sequence":"first","affiliation":[{"name":"Department of Pharmacy Bacha Khan University  Charsadda Khyber Pakhtunkhwa Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mir Azam","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Malakand  Chakdara Khyber Pakhtunkhwa Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3698-0616","authenticated-orcid":false,"given":"Abdullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Malakand  Chakdara Khyber Pakhtunkhwa Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Asghar","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Malakand  Chakdara Khyber Pakhtunkhwa Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Saeed","family":"Jan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Bacha Khan University  Charsadda Khyber Pakhtunkhwa Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdur","family":"Rauf","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Swabi  Swabi Khyber Pakhtunkhwa Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3662-0933","authenticated-orcid":false,"given":"Anees Ahmed","family":"Khalil","sequence":"additional","affiliation":[{"name":"University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences The University of Lahore  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4674-9378","authenticated-orcid":false,"given":"Ahood","family":"Khalid","sequence":"additional","affiliation":[{"name":"University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences The University of Lahore  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samiah","family":"Shahid","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology (IMBB), Research Centre for Health Sciences (RCHS) The University of Lahore  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8452-5343","authenticated-orcid":false,"given":"Mohammed Mansour","family":"Quradha","sequence":"additional","affiliation":[{"name":"College of Education Seiyun University  Seiyun Hadhramawt Yemen"},{"name":"Pharmacy Department, Medical Sciences Aljanad University for Science and Technology  Taiz Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2010.04.004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6437641"},{"issue":"1","key":"e_1_2_11_4_1","first-page":"86","article-title":"Ethnobotanical Study of Upper Siran","volume":"15","author":"Ahmad H.","year":"2009","journal-title":"Journal of Herbs, Spices & Medicinal Plants"},{"issue":"1","key":"e_1_2_11_5_1","first-page":"45","article-title":"Isoproterenol\u2010Induced Dysfunction in Rats' Heart Mitochondria: Protective Role of \n                     Rumex vesicarius\n                   Extract","volume":"36","author":"Ahmed M. M.","year":"2015","journal-title":"Journal of Drug Research of Egypt"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.31925\/farmacia.2021.5.19"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(03)00697-0"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50881-X"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.42078"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/0717-6287-47-56"},{"issue":"4","key":"e_1_2_11_11_1","first-page":"339","article-title":"Isoproterenol\u2010Induced Myocardial Injury and Diastolic Dysfunction in Mice: Structural and Functional Correlates","volume":"59","author":"Brooks W. W.","year":"2009","journal-title":"Comparative Medicine"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00017.2014"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-24021-y"},{"issue":"10","key":"e_1_2_11_14_1","first-page":"235","article-title":"Role of Simvastatin in the Reduction of Oxidative Stress in Isoproterenol Induced Myocardial Infarction in Rats","volume":"3","author":"Gayathri R.","year":"2011","journal-title":"Drug Invention Today"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161126040"},{"issue":"4","key":"e_1_2_11_16_1","first-page":"298","article-title":"Investigation of Ischemia Modified Albumin, Oxidant and Antioxidant Markers in Acute Myocardial Infarction","volume":"11","author":"Hazini A.","year":"2015","journal-title":"Advances in Interventional Cardiology\/Post\u0119py w Kardiologii Interwencyjnej"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112775"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.10.041"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015815624334"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cdt3.34"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27113383"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.870774"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(86)90247-0"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.2374"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.5530\/ijpi.14.2.35"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/15701611113119990003"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10111113"},{"issue":"9","key":"e_1_2_11_28_1","article-title":"Advancements in Myocardial Infarction Management: Exploring Novel Approaches and Strategies","volume":"15","author":"Sachdeva P.","year":"2023","journal-title":"Cureus"},{"issue":"6","key":"e_1_2_11_29_1","first-page":"525","article-title":"The Bioactivity of Certain Medicinal Plants on the Stabilization of RBC Membrane System","volume":"60","author":"Sadique J.","year":"1989","journal-title":"Fitoterapia"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202100706"},{"issue":"3","key":"e_1_2_11_31_1","first-page":"91","article-title":"Resveratrol: A Double\u2010Edged Sword in Health Benefits","volume":"6","author":"Salehi B.","year":"2018","journal-title":"Biomedicine"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.15406\/mojbm.2018.03.00093"},{"issue":"6","key":"e_1_2_11_33_1","first-page":"262","article-title":"Screening of Cardioprotective Effect of Terminalia Arjuna Linn. Bark in Isoproterenol\u2010Induced Myocardial Infarction in Experimental Animals","volume":"5","author":"Sivakumar V.","year":"2014","journal-title":"International Journal of Pharmaceutical Sciences and Research"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-006-0814-x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.187397"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-020-00099-x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bfopcu.2013.03.001"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.4750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T07:24:20Z","timestamp":1745825060000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.4750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/fsn3.4750"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.4750","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e4750"}}