{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:42:22Z","timestamp":1786977742780,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Monosodium glutamate (MSG), a widely used food additive, has been associated with various health concerns, including potential reproductive toxicity. This study investigated the protective effects of black garlic (BG) ethanol extract against MSG\u2010induced ovarian damage in rats. Thirty\u2010two female rats in estrus were randomly divided into four groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098 per group): control (saline), BG (250\u2009mg\/kg BW), MSG (4\u2009mg\/g BW), and BG+MSG (combined treatment). Treatments were administered daily for 14\u2009days. Ovarian tissues were collected for histopathological, immunohistochemical (IHC), and biochemical analyses. Histopathological examination revealed a significant reduction in cystic follicles in the BG+MSG group compared to the MSG group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). IHC analysis showed decreased immunoreactivity of endothelin\u20101 and endothelin\u20102 in the BG+MSG group compared to the MSG group (both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Biochemical assays demonstrated significantly increased follicle\u2010stimulating hormone (FSH), luteinizing hormone (LH), and estradiol levels in the BG+MSG group compared to the MSG group (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), while progesterone levels were significantly lower in the MSG group compared to the BG+MSG group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). These findings suggest that BG ethanol extract may mitigate MSG\u2010induced ovarian dysfunction in rats by alleviating degenerative changes in follicles and modulating hormonal levels. This study provides insights into potential natural interventions for MSG\u2010related reproductive toxicity.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.4766","type":"journal-article","created":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T21:49:09Z","timestamp":1737323349000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Black Garlic Extract Modulates Endothelin Expression and Ovulatory Function in Monosodium Glutamate Treated Rats"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1658-2098","authenticated-orcid":false,"given":"Arzu","family":"Gezer","sequence":"first","affiliation":[{"name":"Vocational School of Health Services Atat\u00fcrk University  Erzurum T\u00fcrkiye"},{"name":"Graduate School of Natural and Applied Sciences, Pharmaceutical Research and Development Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3267-5251","authenticated-orcid":false,"given":"\u015e\u00fckran","family":"Yediel Aras","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Midwifery Kafkas University  Kars T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6359-6249","authenticated-orcid":false,"given":"Mustafa","family":"Ozkaraca","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Pathology Sivas Cumhuriyet University  Sivas T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3584-5252","authenticated-orcid":false,"given":"Nurcan","family":"Kilic Baygutalp","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Biochemistry Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0856-827X","authenticated-orcid":false,"given":"G\u00fclhande","family":"Gundogdu","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Histology and Embryology Kafkas University  Kars T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7581-6109","authenticated-orcid":false,"given":"Ebru","family":"Karadag Sari","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Histology and Embryology Kafkas University  Kars T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8859-7814","authenticated-orcid":false,"given":"G\u00fcrsel","family":"Bedir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Histology and Embryology Ataturk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3140-0755","authenticated-orcid":false,"given":"Hilal","family":"\u00dcst\u00fcnda\u011f","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physiology Erzincan Binali Y\u0131ld\u0131r\u0131m University  Erzincan T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.56499\/jppres21.1312_10.3.397"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"2195","article-title":"Polymorphism of Endothelin\u20101 Gene in Iraqi Infertile Females Under In\u00a0Vitro Fertilization Program","volume":"9","author":"Abdulkareem Z. J.","year":"2023","journal-title":"History of Medicine"},{"key":"e_1_2_9_4_1","first-page":"1","article-title":"Effect of Monosodium Glutamate on the Body System","volume":"44","author":"Adeleke D. A.","year":"2022","journal-title":"World News of Natural Sciences"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527320666210927101257"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934824"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010153"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.21608\/besps.2023.108924.1149"},{"key":"e_1_2_9_9_1","unstructured":"Azordedast P. 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