{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:06:41Z","timestamp":1788401201899,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigates the phytochemical composition and biopharmacological potential of three\n                    <jats:italic>Hypericum<\/jats:italic>\n                    species (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. scabrum<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:italic>H. lysimachioides<\/jats:italic>\n                    , and\n                    <jats:italic>H. uniglandulosum<\/jats:italic>\n                    ) from Turkey. Aqueous and hydroalcoholic extracts were analyzed for their total phenolic content (TPC), total flavonoid content (TFC), and individual components (by the UHPLC\u2013HRMS technique). Antioxidant activities were investigated by DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelating assays. The inhibition effects of the tested extracts on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, amylase, and glucosidase were examined. One hundred compounds were identified in the chemical composition, and specific compounds for the genus\n                    <jats:italic>Hypericum<\/jats:italic>\n                    , such as hyperoside, hypericin, and pseudohypericin, were detected. The highest TPC was detected in the ethanol\/water extract of\n                    <jats:italic>H. lysimachioides<\/jats:italic>\n                    with 69.21\u2009mg GAE\/g. Furthermore, the ethanol\/water extract showed the strongest free radical and reducing effect. The ethanol\/water extracts of the tested\n                    <jats:italic>Hypericum<\/jats:italic>\n                    species were more active in tyrosinase, amylase, and glucosidase than the water extracts. Neuroprotective assessments indicated downregulation of COX\u20102 and NOS\u20102 genes in LPS\u2010stimulated mouse cortex models, alongside modulation of SERT and NET expression, suggesting reduced neuroinflammation and enhanced neurotransmitter release. Molecular docking and dynamics analyses highlighted strong binding interactions, especially in the NET_hyperoside and NET_myricitrin complexes. The results indicate significant therapeutic potential for these extracts, supporting their development as natural agents against oxidative stress, neuroinflammation, and related neurodegenerative diseases.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70069","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T10:14:01Z","timestamp":1744280041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Unlocking New Pharma\/Nutraceutical Frontiers With Neuroprotective Properties of Three\n                    <i>Hypericum<\/i>\n                    Species: A Study Combination With In\u00a0Vitro and In Silico Methodologies"],"prefix":"10.1002","volume":"13","author":[{"given":"Muammer","family":"Bahsi","sequence":"first","affiliation":[{"name":"Faculty of Education Firat University  Elaz\u0131\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta Cristina","family":"Di Simone","sequence":"additional","affiliation":[{"name":"Botanic Garden \u201cGiardino Dei Semplici\u201d, Department of Pharmacy \u201cGabriele d'Annunzio\u201d University  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrina","family":"Zheleva\u2010Dimitrova","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Medical University of Sofia  Sofia Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Biology, Science Faculty Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Cusumano","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo Angeles","family":"Flores","sequence":"additional","affiliation":[{"name":"Botanic Garden \u201cGiardino Dei Semplici\u201d, Department of Pharmacy \u201cGabriele d'Annunzio\u201d University  Chieti Italy"},{"name":"Department of Chemistry, Biology and Biotechnology University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Angelini","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Emiliani","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Veysi","family":"Cetiz","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Harran University  Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Chiavaroli","sequence":"additional","affiliation":[{"name":"Botanic Garden \u201cGiardino Dei Semplici\u201d, Department of Pharmacy \u201cGabriele d'Annunzio\u201d University  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Menghini","sequence":"additional","affiliation":[{"name":"Botanic Garden \u201cGiardino Dei Semplici\u201d, Department of Pharmacy \u201cGabriele d'Annunzio\u201d University  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guistino","family":"Orlando","sequence":"additional","affiliation":[{"name":"Botanic Garden \u201cGiardino Dei Semplici\u201d, Department of Pharmacy \u201cGabriele d'Annunzio\u201d University  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9431-9407","authenticated-orcid":false,"given":"Claudio","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Botanic Garden \u201cGiardino Dei Semplici\u201d, Department of Pharmacy \u201cGabriele d'Annunzio\u201d University  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.55730\/1300-0527.3494"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c06335"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00238-019-01538-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1572-5995(05)80043-2"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"12","article-title":"Essential Oil Composition of Hypericum uniglandulosum Hausskn. 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