{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:26:53Z","timestamp":1792254413838,"version":"4.4.0"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The classical renin\u2010angiotensin system (RAS) axis is implicated in NAFLD development by promoting oxidative stress and inflammation, whereas the nonclassical axis antagonizes its effects. In the present study, we evaluated the effects of resveratrol (RSV), a polyphenol antioxidant, alone and in combination with atorvastatin (AT) on the RAS axes in NAFLD mice. Male C57\/BL6 mice were fed a normal diet (control group) or a high\u2010fat diet (HFD) for 12\u2009weeks to induce NAFLD. Afterwards, the animals received AT (20\u2009mg\/kg), RSV (100\u2009mg\/kg\/day), and AT\u2009+\u2009RSV (20 and 100\u2009mg\/kg\/day) by oral gavage for 4\u2009weeks. NAFLD animals exhibited swollen hepatocytes with numerous fat\u2010containing vacuoles. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were increased in NAFLD mice. Additionally, HFD mice exhibited dyslipidemia, as manifested by increased cholesterol (Chol), triglyceride (TG), and low\u2010density lipoprotein cholesterol (LDL\u2010C), and decreased high\u2010density lipoprotein cholesterol (HDL\u2010C). HFD significantly increased oxidative stress, as manifested by high levels of malondialdehyde and low paraoxonase 1 activity. Additionally, NAFLD mice showed significantly increased IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1 expression and reduced IL\u201010 expression. An imbalance among RAS axes was evident as high expression levels of angiotensinogen, renin, and type 1 angiotensin receptor and reduced expression levels of angiotensin\u2010converting enzyme 2 and angiotensin 1\u20137. RSV ameliorated these changes in NAFLD mice, which were comparable with the beneficial effects of AT. Interestingly, the ameliorative effects of AT increased considerably when it was administered in combination with RSV. Overall, our findings indicate that RSV attenuates HFD\u2010induced NAFLD in mice, particularly when co\u2010administered with AT, at least by regulating the RAS axes, oxidative stress, and inflammation.<\/jats:p>","DOI":"10.1002\/fsn3.70073","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:56:14Z","timestamp":1741733774000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Resveratrol Relieves Hepatic Steatosis and Enhances the Effects of Atorvastatin in a Mouse Model of <scp>NAFLD<\/scp> by Regulating the Renin\u2010Angiotensin System, Oxidative Stress, and Inflammation"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2549-7802","authenticated-orcid":false,"given":"Esmaeel","family":"Babaeenezhad","sequence":"first","affiliation":[{"name":"Nutritional Health Research Center Lorestan University of Medical Sciences  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid","family":"Farahmandian","sequence":"additional","affiliation":[{"name":"Department of Tissue Engineering &amp; 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