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Freeze\u2010dried broccoli powder (BROC) exhibits diverse biological activities, particularly its antioxidant properties. Our study explored the effects of BROC on post\u2010epileptic cognitive function. Male mice with lithium\u2010pilocarpine\u2010induced epilepsy were randomly divided into three groups: control group, model group (basal diet), and broccoli intervention group (basal diet supplemented with 4% BROC). Following 60\u2009days of intervention, cognitive function was evaluated using IntelliCage Learning Tests, Novel Object Recognition, and Shuttle Box Tests. The hippocampal levels of malondialdehyde (MDA) and antioxidant enzyme activities were measured, and the protein expression levels of HO\u20101, NQO1, and Nrf2 were analyzed by Western blot. The results demonstrated that broccoli intervention significantly ameliorated cognitive deficits in epileptic mice, decreased hippocampal MDA levels while enhancing antioxidant enzyme activities, and upregulated the expression of HO\u20101, NQO1, and Nrf2. Consequently, BROC effectively attenuates OS and ameliorates cognitive deficits in TLE mice, suggesting its potential therapeutic value for post\u2010epileptic cognitive dysfunction.<\/jats:p>","DOI":"10.1002\/fsn3.70079","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:47:58Z","timestamp":1741715278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unlocking the Potential of Freeze\u2010Dried Broccoli Powder: A Novel Approach to Enhancing Cognitive Resilience in Temporal Lobe Epilepsy"],"prefix":"10.1002","volume":"13","author":[{"given":"Yanan","family":"Gong","sequence":"first","affiliation":[{"name":"Ningxia Key Laboratory of Craniocerebral Diseases, Incubation Base of National Key Laboratory Ningxia Medical University  Yinchuan 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