{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:41:40Z","timestamp":1784914900323,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to investigate the associations between a dietary index for gut microbiota (DI\u2010GM), flavonoid intake, and female infertility, while exploring age\u2010specific differences in these relationships to identify potential dietary strategies for female infertility prevention. This cross\u2010sectional study focused on female participants aged 18\u201345\u2009years, with data obtained from the 2017\u20132018 cycle of the National Health and Nutrition Examination Survey (NHANES). Weighted multivariable logistic regression models were employed to examine the associations between DI\u2010GM, flavonoid intake, and self\u2010reported female infertility. Age\u2010stratified analyses were performed to evaluate whether these associations varied across reproductive life stages. Higher DI\u2010GM scores were significantly associated with reduced infertility risk (aOR\u2009=\u20090.30, 95% CI: 0.13\u20130.71,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006), with the strongest protective effects observed in women aged &lt;\u200935\u2009years (Q3: aOR\u2009=\u20090.13, 95% CI: 0.03\u20130.58,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007; Q4: aOR\u2009=\u20090.27, 95% CI: 0.09\u20130.77,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.015). Beneficial gut microbiota scores also showed a protective effect (aOR\u2009=\u20090.75, 95% CI: 0.57\u20130.98,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.036). Among women aged \u2265\u200935\u2009years, moderate flavonoid intake (Q2) showed a significant inverse association with female infertility risk (aOR\u2009=\u20090.19, 95% CI: 0.06\u20130.66,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009). Our findings reveal novel evidence that higher DI\u2010GM scores and moderate flavonoid intake are significantly linked to a lower risk of female infertility, with age\u2010specific patterns observed. Higher DI\u2010GM scores showed significant protective effects in younger women (&lt;\u200935\u2009years), while moderate flavonoid intake was protective in women aged \u2265\u200935\u2009years. These findings underscore the potential of personalized dietary strategies targeting gut microbiota composition and flavonoid intake as cost\u2010effective approaches for female infertility prevention and management across different reproductive life stages.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70098","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T04:11:19Z","timestamp":1743221479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Associations of Dietary Index for Gut Microbiota and Flavonoid Intake With Female Infertility in the United States"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5014-4748","authenticated-orcid":false,"given":"Di","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Comprehensive Maternal and Child Health, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Maternal and Child Health, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Maternal and Child Health, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"International Centre for Reproductive Health (ICRH), Department of Public Health and Primary Care Ghent University  Gent Belgium"},{"name":"School of Public Health Universit\u00e9 Libre de Bruxelles (ULB)  Bruxelles Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2028-7510","authenticated-orcid":false,"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Maternal and Child Health, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.06.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/cmi\/7808354"},{"key":"e_1_2_10_4_1","first-page":"2107","volume-title":"Dietary Anthocyanins and Human Health","author":"Blesso C. 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