{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:32:01Z","timestamp":1792225921969,"version":"4.4.0"},"reference-count":81,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Bellardia trixago<\/jats:italic>\n                    <\/jats:styled-content>\n                    (L.) All. (family Orobanchaceae) is a facultative hemiparasitic plant used traditionally to cure many diseases. The present study was designed to evaluate the phenolic constituents, antioxidant, enzyme inhibitory, and cytotoxic properties of the aerial parts of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B. trixago<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Ethyl acetate (EtOAc), ethanol (EtOH), and 70% EtOH extracts were prepared by maceration, while the aqueous extract was prepared by infusion. Rutin, 4\u2010hydroxy benzoic acid, ferulic acid,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010coumaric acid, hyperoside, delphinidin 3,5 diglucoside, kaempferol, and isoquercitrin were identified in most extracts with variable concentrations, but generally, the EtOH or 70% EtOH accumulated the highest contents. The 70% EtOH extract displayed the best antiradical (DPPH\u2009=\u200913.55\u2009mg TE\/g; ATBS\u2009=\u200953.78\u2009mg TE\/g) and ion\u2010reducing (CUPRAC\u2009=\u200950.09\u2009mg TE\/g; FRAP\u2009=\u200924.73\u2009mg TE\/g) properties. The aqueous extract recorded the highest chelating iron power (12.91\u2009mg EDTAE\/g) while EtOAc and EtOH exerted the highest total antioxidant activity (2.29 and 2.49\u2009mmol TE\/g,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). The best cholinesterase (anti\u2010AChE\u2009=\u20092.91\u2009mg GALAE\/g; and anti\u2010BchE\u2009=\u20092.62\u2009mg GALAE\/g) and \u03b1\u2010glucosidase (1.19\u2009mmol ACAE\/g) inhibition activity was recorded from the EtOH extract, while that against the \u03b1\u2010amylase was obtained from the EtOAc extract (0.69\u2009mmol ACAE\/g). The plant was most cytotoxic toward the HT\u201029 cell line, where the best effect was exerted by the 70% EtOH (IC\n                    <jats:sub>50<\/jats:sub>\n                    38.42\u2009\u03bcg\/mL) extract. Furthermore, network pharmacology analysis revealed critical gene targets and pathways associated with the bioactive compounds. Molecular docking studies revealed favorable binding modes and interaction patterns of major compounds with key colon cancer\u2010related proteins, which were further supported by molecular dynamics simulations. As the first investigation into the phenolic composition and pharmacological effects of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B. trixago<\/jats:italic>\n                    <\/jats:styled-content>\n                    , this study highlights its potential as a promising source of bioactive compounds with therapeutic relevance for oxidative stress\u2010related conditions.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70109","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T01:00:23Z","timestamp":1744678823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Biopotential of\n                    <scp>\n                      <i>Bellardia trixago<\/i>\n                    <\/scp>\n                    in Replacing Synthetic Compounds for Health\u2010Promoting Applications: Is It a Promising Candidate?"],"prefix":"10.1002","volume":"13","author":[{"given":"Mehmet Veysi","family":"Cetiz","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry Faculty of Medicine, Harran University  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9600-3526","authenticated-orcid":false,"given":"Sakina","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Botany Faculty of Science, University of Khartoum  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouadio Ibrahime","family":"Sinan","sequence":"additional","affiliation":[{"name":"Department of Biology Science Faculty, Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Senkardes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany Faculty of Pharmacy, Marmara University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Koyuncu","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Faculty of Medicine, Harran University  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgur","family":"Yuksekdag","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Faculty of Medicine, Harran University  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Caprioli","sequence":"additional","affiliation":[{"name":"CHemistry Interdisciplinary Project (CHip), School of Pharmacy, University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"Santanatoglia","sequence":"additional","affiliation":[{"name":"CHemistry Interdisciplinary Project (CHip), School of Pharmacy, University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Sagratini","sequence":"additional","affiliation":[{"name":"CHemistry Interdisciplinary Project (CHip), School of Pharmacy, University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enver","family":"Saka","sequence":"additional","affiliation":[{"name":"Department of Biology Science Faculty, Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulsah","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Biology Science Faculty, Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengusu Hacer","family":"Akgul","sequence":"additional","affiliation":[{"name":"Department of Biology Science Faculty, Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Biology Science Faculty, Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-025-01314-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2025.106000"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202301167"},{"issue":"3","key":"e_1_2_8_5_1","first-page":"257","article-title":"Exploration of Ferulic Acid and Its Derivatives as Potent Anti\u2010Tyrosinase: A Systematic Review","volume":"67","author":"Alifah L. 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