{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:52:46Z","timestamp":1791928366633,"version":"4.3.4"},"reference-count":126,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Prunus mahaleb<\/jats:italic>\n                    <\/jats:styled-content>\n                    has garnered attention as a potent medicinal agent and functional component. We aimed to detect the chemical composition and biological activities of several parts (fruit, leaves, and twigs) of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. mahaleb<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Biological activities were assessed for antioxidant properties, enzyme inhibition, mutagenic\/antimutagenic effects, and antibacterial efficacy. Antioxidant capabilities were evaluated using various assays, including DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelating. The chemical constituents of the extracts were identified and quantified using the HPLC\u2010ESI\u2010MS\/MS method. The effects of enzyme inhibition were examined on some enzymes, including AChE, BChE, tyrosinase, amylase, and glucosidase. The Ames test was used to evaluate the mutagenic and antimutagenic properties of the plant extracts. Furthermore, a broth microdilution assay was employed to evaluate the possible antibacterial effects of the extracts against microorganisms. The methanol extract of twigs showed superior antioxidant capabilities (DPPH: 388.39\u2009mg TE\/g; ABTS: 701.50\u2009mg TE\/g; CUPRAC: 459.05\u2009mg TE\/g; FRAP: 264.99\u2009mg TE\/g). The methanol extract of twigs demonstrated the highest tyrosinase inhibitory activity (61.91\u2009mg KAE\/g). A total of 40 metabolites, mainly flavonoids, were detected through HPLC\u2010ESI\u2010MS\/MS analysis, revealing that ferulic acid, naringenin, and herniarin were the predominant compounds. In the Ames test, the tested extracts exhibited no mutagenic potential. The antimutagenicity assay demonstrated that methanol and ethyl acetate extracts from twigs and leaves were particularly efficient against frameshift and base pair substitution mutations induced by recognized mutagens. The metabolic activation system amplified these strong activities to inhibition rates ranging from 85% to 98%. The results from the antibacterial assay indicated antibacterial effectiveness at dosages between 6.25 and 0.195\u2009mg\/mL, particularly effective against\n                    <jats:italic>\n                      Sarcina lutea,\n                      <jats:styled-content style=\"fixed-case\">Bacillus cereus<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">Candida albicans<\/jats:styled-content>\n                    <\/jats:italic>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Our findings indicate that\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. mahaleb<\/jats:italic>\n                    <\/jats:styled-content>\n                    can serve as a versatile raw material for the development of health\u2010promoting applications, including medicines, cosmeceuticals, and nutraceuticals.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70121","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:24:00Z","timestamp":1743380640000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Exploring the Utility of\n                    <scp>\n                      <i>Prunus mahaleb<\/i>\n                    <\/scp>\n                    Extracts as a Source of Natural Bioactive Compounds for Functional Applications"],"prefix":"10.1002","volume":"13","author":[{"given":"Bayram","family":"Atasagun","sequence":"first","affiliation":[{"name":"Department of Medical Services and Techniques Vocational School of Health Services, Selcuk University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9297-4050","authenticated-orcid":false,"given":"Ahmet","family":"Uysal","sequence":"additional","affiliation":[{"name":"Department of Medical Services and Techniques Vocational School of Health Services, Selcuk University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7278-732X","authenticated-orcid":false,"given":"Noha","family":"Fathallah","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy Future University in Egypt  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0972-0560","authenticated-orcid":false,"given":"Omayma","family":"Eldahshan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University  Cairo Egypt"},{"name":"Faculty of Pharmacy, Center for Drug Discovery Research and Development Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel Nasser","family":"Singab","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University  Cairo Egypt"},{"name":"Faculty of Pharmacy, Center for Drug Discovery Research and Development Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Veyis","family":"Cetiz","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Harran University  Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Biology, Science Faculty Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/01480545.2015.1121273"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2025.106000"},{"issue":"3","key":"e_1_2_8_4_1","first-page":"257","article-title":"Exploration of Ferulic Acid and Its Derivatives as Potent Anti\u2010Tyrosinase: A Systematic Review","volume":"67","author":"Alifah L. 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