{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:56:01Z","timestamp":1790315761793,"version":"4.1.0"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to extract the bioactive components in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Aronia melanocarpa<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. fruit, commonly referred to as chokeberry, using various solvents (80% methanol\u2009+\u20091% formic acid, 80% ethanol, and 70% acetone) individually and to evaluate them through the Neutrosophic\u2010Analytical Hierarchy Process (N\u2010AHP)\u2010based TOPSIS method. The ethanolic (EEA), methanolic (MEA), and acetone (AEA) extracts derived from Aronia fruit were analyzed for total phenolic, flavonoid, and anthocyanin contents, as well as antioxidant, antimicrobial, and cytotoxic activities. The EEA exhibited the highest overall anthocyanin content. The MEA exhibited the highest DPPH levels. The AEA exhibited the highest levels of total phenolic compounds, total flavonoid content, and CUPRAC values. The EEA, MEA, and AEA exhibited IC50 values of 11.65, 11.71, and 10.51\u2009mg\/mL against Caco\u20102 adenocarcinoma cells, respectively. EEA and MEA exhibited superior antimicrobial efficacy compared to AEA. According to the weights determined by N\u2010AHP, the extraction with methanol was found to be the best extraction method according to the TOPSIS analysis results performed on real data. In other words, the extract with the lowest IC50 value and the highest antimicrobial activity was the one extracted with methanol. This study concluded that the N\u2010AHP\u2010based TOPSIS method is a significant multiple decision\u2010making approach for evaluating plant extracts based on established criteria and is applicable to food and phytochemical sciences.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70122","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T14:44:37Z","timestamp":1743432277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Hybrid N\u2010\n                    <scp>AHP<\/scp>\n                    \u2010Based\n                    <scp>TOPSIS<\/scp>\n                    Decision Support Approach for Investigation of the Effect of Different Solvents on the Bioactive Properties, Anticancer, and Antimicrobial Activities of\n                    <scp>\n                      <i>Aronia melanocarpa<\/i>\n                    <\/scp>\n                    Extract"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4207-6797","authenticated-orcid":false,"given":"Gulsum","family":"Ucak Ozkaya","sequence":"first","affiliation":[{"name":"Scientific Research Projects Coordination Unit Mimar Sinan Art Fine University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,30]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1","volume-title":"Nicel Karar Verme Uygulamar\u0131","author":"Akba\u015f F.","year":"2024"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2013.01.010"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf048741x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijfs.16542"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5962\/p.251408"},{"key":"e_1_2_10_7_1","volume-title":"Neutrosophic Sets: An Overview","author":"Broumi S.","year":"2018"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/app13126936"},{"issue":"5","key":"e_1_2_10_9_1","first-page":"2642","article-title":"Coconut Oil\u2010Loaded Chitosan Nanoparticles for the Treatment of Acne Vulgaris: Cytotoxicity, Antibacterial Activity, and Antibiofilm Properties","volume":"27","author":"Cakir\u2010Koc R.","year":"2018","journal-title":"Fresenius Environmental Bulletin"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.30714\/j\u2010ebr.2023.172"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfpe.12978"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2022.114335"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032719.2023.2164893"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.09.045"},{"issue":"1","key":"e_1_2_10_15_1","first-page":"1","article-title":"Single Valued Neutrosophic Numbers and Their Applications to Multicriteria Decision Making Problem","volume":"2","author":"Deli I.","year":"2014","journal-title":"Neutrosophic Sets and Systems"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2021.112018"},{"issue":"4","key":"e_1_2_10_17_1","first-page":"1373","article-title":"Development and Evaluation of Kefir Products Made With Aronia or Elderberry Juice: Sensory and Phytochemical Characteristics","volume":"25","author":"Du X.","year":"2018","journal-title":"International Food Research Journal"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3906\/tar\u20101403\u201063"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3906\/tar-1903-130"},{"issue":"2","key":"e_1_2_10_20_1","first-page":"150","article-title":"The Performance Evaluation of the ASEAN Countries and Turkey in the Sustainable Development Index Framework With the TOPSIS Method","volume":"1","author":"Erdin C.","year":"2017","journal-title":"Yildiz Social Sciences Institute Journal"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e03215"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e04006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2020.1789679"},{"issue":"1","key":"e_1_2_10_24_1","first-page":"1","article-title":"The Analytic Hierarchy Process","volume":"2","author":"Golden B. L.","year":"1989","journal-title":"Applications and Studies, Berlin, Heidelberg"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/app13042334"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10230\u2010014\u20100263\u2010y"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.11002\/kjfp.2020.27.4.457"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-018-3135-z"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cie.2021.107795"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126541"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100028\u20101088306"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scp.2024.101546"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjac.2023.100301"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0377\u20102217(99)00118\u20106"},{"key":"e_1_2_10_35_1","doi-asserted-by":"crossref","unstructured":"Liberatore M. J.1982.\u201cBook Review of the Analytic Hierarchy Process: Planning Priority Setting Resource Allocation by Thomas L. Saaty: Taylor & Francis.\u201d","DOI":"10.1080\/01966324.1982.10737095"},{"issue":"4","key":"e_1_2_10_36_1","first-page":"195","article-title":"Antimicrobial Activity of Extracts From Fruits of Aronia Melanocarpa and Sorbus aucuparia","volume":"11","author":"Liepi\u0146a I.","year":"2013","journal-title":"Environmental and Experimental Biology"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2022.106102"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC4602_12"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/agriculture2030244"},{"issue":"6","key":"e_1_2_10_40_1","first-page":"7","article-title":"Anthocyanins: Antioxidant and\/or Anti\u2010Inflammatory Activities","volume":"1","author":"Miguel M. G.","year":"2011","journal-title":"Journal of Applied Pharmaceutical Science"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2019.2908919"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12040951"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21081098"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020660"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16040525"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/app12031734"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2021.06.020"},{"key":"e_1_2_10_48_1","volume-title":"Neutrosophic AHP Multi Criteria Decision Making Method Applied on the Selection of Learning Management System","author":"Radwan N. M.","year":"2016"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/0952813X.2019.1592236"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0270-0255(87)90473-8"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eiar.2021.106572"},{"issue":"4","key":"e_1_2_10_52_1","first-page":"46","article-title":"Aronia (Chokeberry): An Underutilized, Highly Nutraceutical Plant","volume":"8","author":"Shahin L.","year":"2019","journal-title":"Journal of Medicinally Active Plants"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22122158"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2016.01.019"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf010865b"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)99017-1"},{"key":"e_1_2_10_57_1","first-page":"64","article-title":"Comparative Analysis of AHP, FAHP and Neutrosophic\u2010AHP Based on Multi\u2010Criteria for Adopting ERPS","volume":"41","author":"Slamaa A. A.","year":"2021","journal-title":"Neutrosophic Sets and Systems"},{"key":"e_1_2_10_58_1","first-page":"1","volume-title":"A Unifying Field in Logics: Neutrosophic Logic Philosophy","author":"Smarandache F.","year":"1999"},{"key":"e_1_2_10_59_1","first-page":"103","article-title":"Of Neutrosophic Numbers","volume":"13","author":"Smarandache F.","year":"2016","journal-title":"Critical Review"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.54216\/IJNS.150203"},{"key":"e_1_2_10_61_1","volume-title":"New Trends in Neutrosophic Theory and Applications","author":"Smarandache F.","year":"2016"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1515\/pjfns\u20102016\u20100009"},{"key":"e_1_2_10_63_1","volume-title":"Decision Analysis in the UK Energy Supply Chain Risk Management: Tools Development and Application","author":"Vafadarnikjoo A.","year":"2020"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10479-021-04048-6"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1239505"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/agronomy9080456"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jarmap.2020.100279"},{"key":"e_1_2_10_68_1","volume-title":"Single Valued Neutrosophic Sets","author":"Wang H.","year":"2010"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2005.03.019"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.15388\/Informatica.2017.108"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/info8020051"},{"key":"e_1_2_10_72_1","unstructured":"Yoon K.1980.\u201cHwang. TOPSIS (Technique for Order Preference by Similarity to Ideal Solution)\u2010A Multiple Attribute Decision Making.\u201d"},{"key":"e_1_2_10_73_1","unstructured":"Yoon K. andC. L.Hwang.1980.\u201cMultiple Attribute Decision Making Methods and Applications. A State of the Art Survey.\u201d"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2021.100910"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(98)00102-2"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.70122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T15:36:25Z","timestamp":1764257785000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.70122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,30]]},"references-count":74,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/fsn3.70122"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.70122","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,30]]},"assertion":[{"value":"2025-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70122"}}