{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:01:24Z","timestamp":1790100084188,"version":"4.0.1"},"reference-count":66,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Ganoderma lucidum<\/jats:italic>\n                    (Leyss. ex Fr.) Karst, commonly known as Lingzhi, has long been employed in traditional Chinese medicine for its medicinal properties, particularly in alleviating respiratory issues like cough and asthma. Recognized both as a therapeutic agent and an edible supplement, Lingzhi is celebrated for its health\u2010promoting benefits. Despite its widespread use, the effectiveness of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>G. lucidum<\/jats:italic>\n                    <\/jats:styled-content>\n                    in treating pneumonia has not been extensively studied, highlighting the need for further research. This research aimed to evaluate the potential of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>G. lucidum<\/jats:italic>\n                    <\/jats:styled-content>\n                    in pneumonia treatment and to uncover the mechanisms behind its effects, specifically examining how its active constituents influence inflammatory pathways. The study utilized approaches such as network pharmacology, bioinformatics, molecular docking, and in\u00a0vivo experiments. High\u2010performance liquid chromatography (HPLC) and liquid chromatography\u2013mass spectrometry (LC\u2013MS) analyses revealed eight triterpenoids in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>G. lucidum<\/jats:italic>\n                    <\/jats:styled-content>\n                    , with ganodermanontriol being the most prominent. Molecular docking studies anticipated the interactions between these compounds and target proteins, while in\u00a0vivo experiments on pneumonia\u2010induced rat models assessed the efficacy of ganodermanontriol. Additionally, HPLC and LC\u2013MS confirmed the presence of eight triterpenoids in the ethanol extract of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>G. lucidum<\/jats:italic>\n                    <\/jats:styled-content>\n                    , predominantly ganodermanontriol. Network pharmacology and molecular docking identified key genes\u2014including TNF, EGFR, ESR1, HIF1A, HSP90AA1, and SRC\u2014that played significant roles in the regulation of inflammatory pathways. In\u00a0vivo results demonstrated that ganodermanontriol treatment mitigated lung tissue damage in rats with experimentally induced pneumonia by reducing the release of inflammatory mediators. Further mechanistic studies showed that ganodermanontriol downregulated TNF\u2010\u03b1 and inhibited the NF\u2010\u03baB\/MAPKs signaling pathways. These findings suggested that ganodermanontriol holds promising potential as an anti\u2010inflammatory agent for pneumonia by targeting the TNF\/NF\u2010\u03baB\/MAPKs signaling pathway, offering a novel therapeutic approach.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70123","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T08:23:48Z","timestamp":1743150228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Network Pharmacology and Experimental Validation Reveal Ganodermanontriol Modulates Pneumonia via\n                    <scp>TNF<\/scp>\n                    \/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    \/\n                    <scp>MAPKs<\/scp>\n                    Signaling Pathway"],"prefix":"10.1002","volume":"13","author":[{"given":"Shizhan","family":"Deng","sequence":"first","affiliation":[{"name":"Wanbei Coal Electric Group General Hospital  Suzhou Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dequan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Wanbei Coal Electric Group General Hospital  Suzhou Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggan","family":"Dong","sequence":"additional","affiliation":[{"name":"Wanbei Coal Electric Group General Hospital  Suzhou Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Orthopedic Trauma Faculty Henan University of Chinese Medicine  Zhengzhou Henan 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Electric Group General Hospital  Suzhou Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8171-5304","authenticated-orcid":false,"given":"Heng","family":"Tang","sequence":"additional","affiliation":[{"name":"Wanbei Coal Electric Group General Hospital  Suzhou Anhui 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