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The obtained HSCG and CSCG extracts contained mainly chlorogenic acid derivatives, according to liquid chromatography\u2010mass spectrometer chromatogram. The glycation process was performed by using bovine serum albumin (BSA)\/ glucose system with 3\u2009weeks incubation. In the presence of HSCG and CSCG extracts at 250\u2009\u03bcg\/mL, after thermal treatment (pasteurization and sterilization) and in\u00a0vitro digestion, the glycation process through the fructosamine, AGEs, and amyloid cross \u03b2 structure formation was monitored, and these extracts exhibited an anti\u2010glycation property at early and advanced stages after pasteurization and in\u00a0vitro digestion compared to no thermal treatment. However, at high temperature of sterilization, the suppress of anti\u2010glycation property had resulted and were related with the amount of antioxidant and the ability of antioxidant scavenging as presented in a dose manner. The calculated % caffeine bio\u2010accessibility of HSGC extracts was 65.8%, 64.8%, and 52.4% in non\u2010thermal, pasteurized, and sterilized samples while the higher bio\u2010accessibility was found in CSCG sample as of 67.4, 66.6, and 63.1, respectively. A high correlation of TPC values, thermal treatments and in\u00a0vitro digestions with the AGEs was detected. Polyphenols and caffeine content in these extracts were found to be responsible for the AGEs and amyloid cross \u03b2 structure inhibition which might potentially reduce the risk of Alzheimer's disease.<\/jats:p>","DOI":"10.1002\/fsn3.70131","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T07:49:11Z","timestamp":1745999351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Impact of Thermal Treatment and In\u00a0Vitro Digestion on Antioxidant Activity and Anti\u2010Glycation Properties of Antioxidant Crude Extract From Hot and Cold Brew Spent Coffee Ground"],"prefix":"10.1002","volume":"13","author":[{"given":"Onamon","family":"Chongsrimsirisakhol","sequence":"first","affiliation":[{"name":"Department of Product Development, Faculty of Agro\u2010Industry Kasetsart University  Bangkok 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