{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T15:39:01Z","timestamp":1764257941723,"version":"3.46.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Jelly fig (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Ficus pumila<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. var.\n                    <jats:italic>awkeotsang<\/jats:italic>\n                    ) a species unique to Taiwan has been used for centuriesas sweets and snacks. It also has potential for medicinal purposes. In this study, the functional efficacy of the extracts of the achenes of different strains of jelly figs was compared. We found that the 80% methanol extract of the Hong\u2010jiou strain had a favorable inhibitory effect on the glycolytic enzymes. Furthermore, 3T3\u2010L1 cells were used to assess whether the extract of the Hong\u2010jiou strain can help regulate the transportation and utilization of glucose in the body and to investigate the insulin\u2010related signal transmission and regulation. According to the results of Oil Red O staining, the Hong\u2010jiou extract inhibited the formation of lipid droplets in both the prevention group and the curing group, and the determination of triglyceride content also showed that it reduced fat accumulation and the degree of differentiation. The three concentrations of the prevention group and the curing group revealed that the increase in glucose uptake was concentration dependent. Based on the comprehensive research results, the prevention group 200\u2009\u03bcg\u00b7mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    (p\u2010200 group) was identified to have the greatest potential to inhibit obesity and improve hyperglycemia. According to the analysis of related protein expression based on the mRNA reverse transcription assay, the Hong\u2010jiou extract affected the mRNA expressions of PPAR\u03b3, SREBP\u20101c, IRS1, LIPE, and CPT1 to reduce the degree of differentiation and the accumulation of fatty acids as well as increase glucose uptake, thereby having the potential hypoglycemic and anti\u2010obesity effects.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70176","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T01:08:26Z","timestamp":1744765706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic Regulation Mechanisms of the Hypoglycemic and Anti\u2010Obesity Effects of\n                    <i>Ficus pumila<\/i>\n                    L. Var.\n                    <i>awkeotsang<\/i>\n                    Achene Extracts in\n                    <scp>3T3<\/scp>\n                    \u2010\n                    <scp>L1<\/scp>\n                    Cells"],"prefix":"10.1002","volume":"13","author":[{"given":"Yu\u2010Siang","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Horticulture and Landscape Architecture National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao\u2010Ho","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Horticulture and Landscape Architecture National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Tay","family":"Shyu","sequence":"additional","affiliation":[{"name":"Department of Horticulture and Landscape Architecture National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9254-9716","authenticated-orcid":false,"given":"Sz\u2010Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Horticulture and Landscape Architecture National Taiwan University  Taipei Taiwan"},{"name":"Food Safety Center National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bionut.2014.07.009"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2014.953455"},{"key":"e_1_2_9_4_1","unstructured":"Chang C. C.2008.\u201cPreliminary Studies of Components of Ficus Awkeotsang Makino With Antioxidative Activity.\u201dMaster Thesis National Taiwan University Taipei Taiwan."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2003.10.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061547"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.03.038"},{"key":"e_1_2_9_8_1","unstructured":"Chen Y. Y.2015.\u201cBis\u2010Demethoxycurcumin (BDMC) Inhibits Adipogenesis in 3T3\u2010L1 Preadipocytes and Suppresses Obesity in High\u2010Fat Diet\u2010Feeding.\u201dMaster Thesis National Taiwan University Taipei Taiwan."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801816-3.00047-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7fo01724c"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666160905150419"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.12.035"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2019.105321"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211\u20105463.12635"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-018-0738-0"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/fermentation7040297"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf901376x"},{"key":"e_1_2_9_18_1","unstructured":"Huang Y. S.2020.\u201cStudy on the Effect ofFicus pumilaL. var.awkeotsangAchene Extract on Hypoglycemia and Anti\u2010Obesity.\u201dMaster Thesis National Taiwan University Taipei Taiwan."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.161968"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.9.1096"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb1961.53.1247"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf401190y"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2006.234"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104393"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11050981"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.12.039"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.09.006"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-014-1526-9"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061474"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2004.08.023"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.09.064"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.4081\/ijas.2015.3875"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.948702"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.03.015"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.153064"},{"issue":"5","key":"e_1_2_9_36_1","first-page":"39","article-title":"An Overview on Dietary Fiber'","volume":"25","author":"Sharma B. 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