{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:17:39Z","timestamp":1769638659876,"version":"3.49.0"},"reference-count":84,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ulcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent episodes of inflammation and tissue damage, with limited treatment options. This study aimed to investigate the effects of collagen peptides and\n                    <jats:italic>Saccharomyces boulardii<\/jats:italic>\n                    on acetic acid (AA)\u2010induced colitis. Thirty\u2010six male Sprague\u2013Dawley rats were randomly divided into the following four groups: normal control (NC), colitis control (CC), collagen peptide (CP; 0.6\u2009g\/kg\/day), and\n                    <jats:italic>S. boulardii<\/jats:italic>\n                    (SB; 250\u2009mg\/day). Colitis was induced by an intrarectal administration of AA in all groups except NC, and treatments were administered daily for 7\u2009days. The therapeutic effects were evaluated by assessing the disease activity index (DAI), colon mass index, macroscopic and microscopic tissue damage, histopathological changes, zonula occludens (ZO)\u20101 protein expression, and myeloperoxidase (MPO) activity. The results showed that CP and SB treatments substantially alleviated DAI scores (\n                    <jats:italic>p\u2009&lt;<\/jats:italic>\n                    \u20090.05) and reduced the colon mass index. Colon macroscopic and microscopic damages improved compared to the CC group (\n                    <jats:italic>p\u2009&lt;<\/jats:italic>\n                    \u20090.01). Histologically, both treatments reduced inflammatory cell infiltration, crypt damage, and ulceration, with CP showing a slightly more pronounced effect. Immunohistochemical analysis revealed significant restoration of ZO\u20101 protein expression in the treated groups, indicating improvement in intestinal barrier integrity (\n                    <jats:italic>p\u2009&lt;<\/jats:italic>\n                    \u20090.01). Furthermore, MPO activity was reduced in both CP and SB groups, significantly in the SB group (\n                    <jats:italic>p\u2009&lt;<\/jats:italic>\n                    \u20090.01). These findings are consistent with previous studies that highlight the anti\u2010inflammatory and barrier\u2010enhancing effects of collagen peptides and probiotics in UC models.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70189","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T23:47:32Z","timestamp":1745020052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Collagen Peptides and\n                    <i>Saccharomyces boulardii<\/i>\n                    <scp>CNCM<\/scp>\n                    I\u2010745 Attenuate Acetic Acid\u2010Induced Colitis in Rats by Modulating Inflammation and Barrier Permeability"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0507-7122","authenticated-orcid":false,"given":"\u00d6yk\u00fc","family":"Alt\u0131nok","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University  Istanbul Turkey"},{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences Fenerbah\u00e7e University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-301X","authenticated-orcid":false,"given":"Murat","family":"Ba\u015f","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences Acibadem Mehmet Ali Aydinlar University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7553-5435","authenticated-orcid":false,"given":"Elif","family":"Gelenli Dolanbay","sequence":"additional","affiliation":[{"name":"Department of Histology &amp; Embryology, School of Medicine Istanbul Medeniyet University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4820-1904","authenticated-orcid":false,"given":"Meltem","family":"Kolgazi","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine Acibadem Mehmet Ali Aydinlar University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6209-8635","authenticated-orcid":false,"given":"Tugay","family":"Mert","sequence":"additional","affiliation":[{"name":"Department of Histology &amp; Embryology, School of Medicine Istanbul Medeniyet University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3953-7131","authenticated-orcid":false,"given":"\u00dcnal","family":"Uslu","sequence":"additional","affiliation":[{"name":"Department of Histology &amp; Embryology, School of Medicine Istanbul Medeniyet University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u2010114572"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201010400\u2010y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/life11030195"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X09354136"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.22038\/IJBMS.2024.75889.16426"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phanu.2014.10.001"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319\u20103767.173753"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010021\u201004094\u20105"},{"issue":"5","key":"e_1_2_11_10_1","first-page":"471","article-title":"Expression and Release of Leptin and 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