{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:32:34Z","timestamp":1790839954528,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Doxorubicin (DOX) is the most widely used chemotherapeutic agent to treat various tumors. DOX treatment can damage many organs, including the brain, by causing oxidative stress. Several antioxidant substances can lessen the effects of DOX or make antioxidant defense systems work faster. Propolis (PROP) is a powerful agent with various healing effects, including antioxidant, antiproliferative, and anti\u2010inflammatory. The point of this study is to look at the histopathological changes, apoptosis, and antioxidant effects of DOX on brain damage in rats. To find out what kinds of phytochemicals were in PROP from the Karl\u0131ova region of Bing\u00f6l province, ultra\u2010high\u2010performance liquid chromatography (UHPLC\u2010Orbitrap\u2010HRMS) was used. Then, we made an ethanol extract of it. A total of 28 healthy male Wistar albino rats, each 12\u2009weeks old and weighing between 220 and 250\u2009g, were included in the study. Rats were divided into four groups: control, PROP, DOX, and PROP+DOX. We applied the relevant treatments to the determined groups. Following the application, we decapitated the rats under the appropriate conditions and collected blood and brain tissue samples. We examined oxidative stress parameters in blood samples and used brain tissue samples for histopathological, biochemical, and molecular analyses. We determined DOX levels in the brain tissue samples using UHPLC\u2010Orbitrap\u2010HRMS. The findings obtained showed that the PROP extract improved DOX\u2010induced brain tissue damage. In addition, PROP extract attenuated DOX\u2010induced brain tissue inflammation, ER stress, apoptosis, and oxidative stress.<\/jats:p>","DOI":"10.1002\/fsn3.70194","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T23:45:04Z","timestamp":1745365504000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Propolis Extract Reduces Doxorubucin\u2010Induced Brain Damage by Regulating Inflammation,\n                    <scp>ER<\/scp>\n                    Stress, Oxidative Stress, and Apoptosis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5091-1262","authenticated-orcid":false,"given":"Volkan","family":"Gelen","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine Kafkas University  Kars T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Ba\u015fe\u011fmez","sequence":"additional","affiliation":[{"name":"Ac\u0131payam Vocational High School, Department of Veterinary, Laboratory and Veterinary Health Program Pamukkale University  Denizli T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130nan","family":"Dursun","sequence":"additional","affiliation":[{"name":"Center of Research and Application Center Bing\u00f6l University  Bing\u00f6l T\u00fcrkiye"},{"name":"Department of Crop and Animal Production, Vocational School of Food, Agriculture and Livestock Bing\u00f6l University  Bing\u00f6l T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan","family":"\u00c7inar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicolog, Faculty of Medicine Kastamonu University  Kastamonu T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adem","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Science Erzurum Technical University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"issue":"9","key":"e_1_2_10_2_1","first-page":"160","article-title":"Amelioration of Cisplatin Induced Testicular Injury by Different Garlic Preparations in Experimental Rat","volume":"5","author":"Abd El\u2010Gany A. 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