{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:48:17Z","timestamp":1781707697199,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","award":["KSN2012320"],"award-info":[{"award-number":["KSN2012320"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","award":["KSN2511030"],"award-info":[{"award-number":["KSN2511030"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Radiation therapy has been used to treat cancer; however, the associated DNA damage and adverse effects in the surrounding tissues remain major concerns. In radiation injury, several natural remedies can effectively relieve symptoms with minimal side effects.\n                    <jats:italic>Cicadidae Periostracum<\/jats:italic>\n                    (CP, also called \u201cSun\u2010Tae\u201d) is the cast\u2010off shell of\n                    <jats:italic>Cryptotympana pustulata<\/jats:italic>\n                    Fabricius and has been traditionally used for several pharmacological actions. This study investigated the protective effects of CP water extract (CPE) on irradiated testicular tissue and spermatogenesis. The chemical constituents of CPE were analyzed using a high\u2010performance liquid chromatography system equipped with a mass detector and were determined to be dimeric\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl dopamine derivatives. The testes and epididymal tissues of male C57BL\/6 mice orally pretreated with CPE (25 and 50\u2009mg\/kg) 24\u2009h and 15\u2009min before radiation exposure (5\u2009Gy) were collected for analysis. CPE pretreatment ameliorated radiation\u2010induced apoptosis in the testes and inhibited weight loss in the epididymis compared to those of the irradiated group. Treatment with high\u2010dose CPE prevented the radiation\u2010induced decrease in the epithelial height of seminiferous tubules. In addition, the morphology, motility, and number of damaged sperm cells following radiation exposure were alleviated by CPE treatment. Furthermore, the dose\u2010dependent antioxidative activity of CPE was confirmed in 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl and 2,2\u2032\u2010azinobis\u2010(3\u2010ethylbenzothiazoline\u20106\u2010sulphonic acid) radical scavenging assays, and reactive oxygen species generation by hydrogen peroxide was reduced by CPE treatment in\u00a0vitro. Our findings suggest that pretreatment with CPE can ameliorate testicular tissue damage and sperm degeneration via the antioxidative properties of CPE in radiation\u2010injured testis tissue.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70198","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:40:16Z","timestamp":1745541616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Protective Effect of Cast\u2010Off Skin of\n                    <i>Cicadidae Periostracum<\/i>\n                    Water Extract in a Radiation\u2010Induced Testicular Injury Mice Model"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4414-3495","authenticated-orcid":false,"given":"Yun\u2010Soo","family":"Seo","sequence":"first","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Mok","family":"Ryu","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyeong","family":"Jeong","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goya","family":"Choi","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong Cheol","family":"Moon","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je\u2010Oh","family":"Lim","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon\u2010Hwa","family":"Nam","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Republic of Korea"},{"name":"Department of Crop Science &amp; Biotechnology Jeonbuk National University  Jeonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2180-4860","authenticated-orcid":false,"given":"Joong\u2010Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8179-5137","authenticated-orcid":false,"given":"Sueun","family":"Lee","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1220497"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7860\/jcdr\/2017\/23927.9886"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1950"},{"issue":"4","key":"e_1_2_10_5_1","first-page":"381","article-title":"Managing the Adverse Effects of Radiation Therapy","volume":"82","author":"Berkey F. 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