{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:14:20Z","timestamp":1792206860218,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The phenolic composition, antioxidant capacity, and enzyme inhibition activities of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Mangifera indica<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. leaf (MLs) ethanol extract were comprehensively evaluated to explore its therapeutic and industrial applications. Quantitative profiling of 21 phenolic compounds was performed using the LC\u2013MS\/MS method, with vanillic acid (1242.47\u2009\u03bcg\/L), gallic acid (283.58\u2009\u03bcg\/L), and quercetin (102.40\u2009\u03bcg\/L) identified as the most abundant constituents. Antioxidant activities were assessed through DPPH, ABTS, FRAP, and CUPRAC assays, revealing moderate radical scavenging (DPPH: 26.87%\u2009\u00b1\u20092.25%, ABTS: 14.65%\u2009\u00b1\u20091.83%) and metal reduction capacities (FRAP: 0.118\u2009\u00b1\u20090.07, CUPRAC: 0.172\u2009\u00b1\u20090.03). In addition, MLs extract demonstrated dose\u2010dependent inhibitory effects on acetylcholinesterase (AChE, IC\n                    <jats:sub>50<\/jats:sub>\n                    : 18.73\u2009\u03bcg\/mL), butyrylcholinesterase (BChE, IC\n                    <jats:sub>50<\/jats:sub>\n                    : 8.56\u2009\u03bcg\/mL), and \u03b1\u2010glucosidase (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 10.83\u2009\u03bcg\/mL), highlighting its potential in the management of neurodegenerative diseases such as Alzheimer's and metabolic disorders including diabetes. The findings emphasize the bioactive potential of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M. indica<\/jats:italic>\n                    <\/jats:styled-content>\n                    leaves, positioning them as a promising resource for sustainable valorization. By showcasing the applicability of this agricultural by\u2010product, the study provides a foundation for innovations in the food, nutraceutical, and pharmaceutical sectors. Nevertheless, further in\u00a0vivo and clinical investigations are essential to fully validate their safety and therapeutic efficacy.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70263","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:35:13Z","timestamp":1746851713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Phenolic Content, Antioxidant Capacity, and Therapeutic Potential of Mango (\n                    <i>Mangifera indica<\/i>\n                    L.) Leaves"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4677-8104","authenticated-orcid":false,"given":"Mesut","family":"I\u015f\u0131k","sequence":"first","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering Bilecik \u015eeyh Edebali University  Bilecik T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrah","family":"Dikici","sequence":"additional","affiliation":[{"name":"Science and Technology Application and Research Center Aksaray University  Aksaray T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevgi","family":"Alt\u0131n","sequence":"additional","affiliation":[{"name":"Erzincan Binali Y\u0131ld\u0131r\u0131m University Faculty of Science and Art, Department of Chemistry  Erzincan T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemalettin","family":"Alp","sequence":"additional","affiliation":[{"name":"Erzincan Binali Y\u0131ld\u0131r\u0131m University Faculty of Science and Art, Department of Chemistry  Erzincan T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevser K\u00fcbra","family":"K\u0131rbo\u011fa","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering Bilecik \u015eeyh Edebali University  Bilecik T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekrem","family":"K\u00f6ksal","sequence":"additional","affiliation":[{"name":"Erzincan Binali Y\u0131ld\u0131r\u0131m University Faculty of Science and Art, Department of Chemistry  Erzincan T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3667-6902","authenticated-orcid":false,"given":"\u015e\u00fckr\u00fc","family":"Beydemir","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Anadolu University  Eski\u015fehir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c05619"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11151899"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2022.08.032"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09637480600798132"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifset.2005.06.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/1811199a0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v15i9.8"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2021.104225"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2011.06.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21935"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20102952(61)90145\u20109"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2018.11.045"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116378"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010017\u20100449\u2010y"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202300654"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12433"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2015.366.371"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2019.32806.7897"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694\u2010021\u201001050\u20101"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202200143"},{"issue":"5","key":"e_1_2_10_22_1","first-page":"62","article-title":"Mangiferin and Antioxidant Capacity From Mango (Mangifera indica L.) 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