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However, SCGs also represent an underexplored and sustainable source of bioactive compounds, particularly chlorogenic acid (CGA), known for its antioxidant, anti\u2010inflammatory, and antimicrobial properties. This systematic review evaluates and compares various conventional and non\u2010conventional extraction methods for CGA from SCGs, assessing their efficacy in terms of extraction yield, environmental impact, cost\u2010efficiency, and processing time, factors often overlooked in earlier studies. Ultrasound\u2010assisted extraction (UAE) emerged as the most effective technique, yielding the highest quantity of CGA (587.7\u2009\u00b1\u200946.6\u2009mg\/g), using ethanol as a solvent with a solid\u2010to\u2010liquid ratio of 1:30. UAE was also identified as the most environmentally friendly technique. In contrast, conventional solvent extraction (CSE) provided a moderate CGA yield (39.5\u2009\u00b1\u20092.1\u2009mg\/g) using water as a solvent and was the most cost\u2010efficient technique. Microwave\u2010assisted extraction (MAE) offered the fastest extraction time with a CGA yield of 84\u2009\u00b1\u20092.8\u2009mg\/g. By integrating technical performance with sustainability considerations, this study offers new insights into the optimization of SCG valorization. Furthermore, it supports the advancement of circular bioeconomy strategies through the efficient recovery of high\u2010value bioactive compounds.<\/jats:p>","DOI":"10.1002\/fsn3.70315","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T07:29:53Z","timestamp":1751009393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Optimizing Chlorogenic Acid Extraction From Spent Coffee Grounds: A Comparative Review of Conventional and Non\u2010Conventional Techniques"],"prefix":"10.1002","volume":"13","author":[{"given":"Mariam","family":"Ramadan","sequence":"first","affiliation":[{"name":"Department of Nutrition and Health, College of Medicine and Health Sciences United Arab Emirates University  Al Ain 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