{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:09:45Z","timestamp":1778929785672,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","award":["TU\u2010DSPP\u20102024\u2010260"],"award-info":[{"award-number":["TU\u2010DSPP\u20102024\u2010260"]}],"id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Hayphaene thebaica<\/jats:italic>\n                    (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. thebaica<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) is thought to be effective in treating several diseases and has possible anti\u2010toxic impacts. Gentamycin (GM) toxicity in internal organs is mostly induced by oxidative stress production. Therefore, the current study aimed to examine the protective effect of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. thebaica<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) against gentamycin\u2010induced renal toxicity. Twenty\u2010four male mice were allocated into four groups: first group administered saline orally as a control, the second group administered\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. thebaica<\/jats:italic>\n                    <\/jats:styled-content>\n                    extract (5%) for 2\u2009weeks, third group injected intraperitoneally with GM (100\u2009mg\/kg, daily) for 15\u2009days, and fourth group served as the protective one, receiving doses used in second and third groups for 2\u2009weeks. To examine kidney function, serum was extracted. Renal tissues were collected and examined for gene expression, histopathology, and immunohistochemistry for nuclear factor kappa B (NF\n                    <jats:sub>k<\/jats:sub>\n                    B), transforming growth factor beta\u20101 (TGF\u2010\u03b21), and tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) immunoreactivity. Serum levels of creatinine, uric acid, and urea were all increased after gentamicin injection. TGF\u2010\u03b21 and cyclooxygenase\u20102 (COX2) were upregulated in renal tissues of the gentamycin group compared to the control and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. thebaica<\/jats:italic>\n                    <\/jats:styled-content>\n                    groups using real\u2010time quantitative PCR (RT\u2010qPCR) analysis, unlike genes of oxidative stress markers, nuclear factor erythroid 2\u2010related factor 2 (Nrf2) was downregulated and was ameliorated by\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. thebaica<\/jats:italic>\n                    <\/jats:styled-content>\n                    pre\u2010administration. Immunoreactivity of genes of TGF\u2010\u03b21, NF\n                    <jats:sub>k<\/jats:sub>\n                    B, and TNF\u2010\u03b1 was significantly immunoreacted and expressed in GM\u2010injected mice and was normalized and ameliorated in the protective group. There were deformities in renal histology represented by degenerative changes in the renal glomerulus, which was surrounded by a wide capsular space, degeneration in the tubular epithelium, and an increase in the accumulation of acidophilic proteinaceous substances within the lumens of some tubules in the gentamycin\u2010injected group compared to the protective group. These deformities were ameliorated by\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Hyphaene thebaica<\/jats:italic>\n                    <\/jats:styled-content>\n                    administration in the protective group.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70345","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T02:09:51Z","timestamp":1748398191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nephroprotective Impacts of\n                    <scp>\n                      <i>Hyphaene thebaica<\/i>\n                    <\/scp>\n                    (Doum) Against Gentamicin\u2010Induced Renal Toxicity Through Different Signaling Pathways"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5415-0448","authenticated-orcid":false,"given":"Saed A.","family":"Althobaiti","sequence":"first","affiliation":[{"name":"Department of Biology Turabah University College, Taif University  Taif Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.9734\/ajrb\/2019\/v5i330091"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.29261\/pakvetj\/2023.027"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"559","article-title":"Allicin and Lycopene Possesses a Protective Effect Against Methotrexate\u2010Induced Testicular Toxicity in Rats","volume":"43","author":"Aboubakr M.","year":"2023","journal-title":"Pakistan Veterinary Journal"},{"issue":"1","key":"e_1_2_10_5_1","first-page":"15","article-title":"The Effect of Arabic Gum on Gentamycin Nephrotoxicity in Mice: A Pathological Study","volume":"22","author":"Alhyali L. 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