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It is still mostly unknown whether causal mechanisms connect dietary exposures to AML, particularly through the gut microbiota and host metabolism. A two\u2010sample Mendelian randomization (MR) analysis was conducted using genome\u2010wide association study (GWAS) data to assess the causal effect of 20 routine dietary factors on AML. A two\u2010step MR framework was employed to assess the mediating roles of gut microbiota and host metabolites. Sensitivity analyses, including inverse variance weighted (IVW), MR\u2010Egger, and MR\u2010PRESSO, were performed to ensure the robustness of results. Processed meat consumption was causally associated with an increased risk of AML (IVW OR\u2009=\u200915.111; 95% CI\u2009=\u20091.253\u2013182.262;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.033). The gut microbiota\u2010associated L\u2010histidine degradation I pathway was identified as a pro\u2010carcinogenic mediator, accounting for 19.5% of the effect. Conversely, host metabolites, including circulating glycerol levels and the free cholesterol\u2010to\u2010total lipids ratio in very large high\u2010density lipoprotein (HDL), functioned as protective mediators. No substantial horizontal pleiotropy or heterogeneity was observed, thereby reinforcing the validity of these findings. This research offers a new understanding of the role of processed meat in the development of AML via the microbiota\u2010metabolite axis and emphasizes possible metabolic compensatory pathways.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70456","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T04:10:54Z","timestamp":1750651854000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetically Predicted Gut Microbiota and Host Metabolites Mediate the Causal Link Between Dietary Factors and Acute Myeloid Leukemia"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-3808","authenticated-orcid":false,"given":"Jiading","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Shenzhen University General Hospital, International Cancer Center, Hematology Institution, Haoshi Cell Therapy Institute of Shenzhen University, Shenzhen University Medical School Shenzhen University  Shenzhen China"},{"name":"Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National\u2010Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Hematological Diseases, Department of Hematology, The 2nd Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangcheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Shenzhen University General Hospital, International Cancer Center, Hematology Institution, Haoshi Cell Therapy Institute of Shenzhen University, Shenzhen University Medical School Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Shenzhen University General Hospital, International Cancer Center, Hematology Institution, Haoshi Cell Therapy Institute of Shenzhen University, Shenzhen University Medical School Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Shenzhen University General Hospital, International Cancer Center, Hematology Institution, Haoshi Cell Therapy Institute of Shenzhen University, Shenzhen University Medical School Shenzhen University  Shenzhen 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