{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:36:55Z","timestamp":1790951815540,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T00:00:00Z","timestamp":1750550400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012421","name":"Agricultural Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["CAAS\u2010ASTIP\u20102019\u2010IAR"],"award-info":[{"award-number":["CAAS\u2010ASTIP\u20102019\u2010IAR"]}],"id":[{"id":"10.13039\/501100012421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bee pollen and its extracts have been used for decades as therapeutic agents or health food supplements to alleviate chronic nonbacterial prostatitis (CNP). However, the functional compounds in bee pollen that are anti\u2010CNP remain still unclear. In this study, we evaluated the anti\u2010CNP properties of six principal phenolamides in bee pollen. Our results provide compelling evidence that the anti\u2010CNP property of bee pollen may be ascribed to its abundance of phenolamides. Particularly, di\u2010\n                    <jats:italic>p<\/jats:italic>\n                    \u2010Coumaroyl spermidine can alleviate CNP by upregulating autophagy via the AMPK\/mTOR signaling pathway and regulating gut microbiota, based on the cellular and rat models. Additionally, our finding may provide a novel insight into the gut\u2013prostate axis by regulating di\u2010\n                    <jats:italic>p<\/jats:italic>\n                    \u2010Coumaroyl spermidine. This is the first report that di\u2010\n                    <jats:italic>p<\/jats:italic>\n                    \u2010Coumaroyl spermidine in bee pollen possesses the anti\u2010prostatitis function. This paper will likely be helpful further to develop functional foods, personalized nutraceuticals, and medicine from bee pollen.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70467","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T02:40:02Z","timestamp":1750646402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Di\u2010\n                    <i>p<\/i>\n                    \u2010Coumaroyl Spermidine From Bee Pollen Alleviates Chronic Nonbacterial Prostatitis"],"prefix":"10.1002","volume":"13","author":[{"given":"Jiawen","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences Capital Medical University  Beijing 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